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Pioneering work led by @Siyan_Cao's lab #XinYao #KaimingMa and rad input @DavidBallardMD #TeamScience bench-bedside-scanner fistula group, that sets it up to study fistula healing and interventions to achieve this, including targeting IFN gamma pathways @WashUMedIBD @WashUMedGastro @WashUDeptMed @WashUMedMIR #RandolphLab @washu_pathology Novel mouse models for perianal fistulizing Crohn’s disease reveal therapeutic value of interferon-γ antagonists Xin Yao, Kaiming Ma, David H. Ballard, Echo Zhu, Xiuli Liu, Lingjie Huang, Chuwen Tian, James D. Quirk, Heather S. Ruiz, Tingyi Tan, Matthew A. Ciorba, Gwendalyn J. Randolph, Parakkal Deepak, Siyan Cao bioRxiv 2026.06.04.730162 biorxiv.org/content/10.64898…
Washington University developed 3 mouse models of perianal fistulizing Crohn’s. IFN-γ lit up in fistula tissue, linked to EMT scarring programs, and blocking it improved healing in mice. biorxiv.org/content/10.64898…
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