Behavioral constraints left unaddressed have no biological workaround. If that behavior is directly involved in my health the same negative-outcome signal keeps firing.
The problem compounds when the survival mechanisms themselves — ANS functions governing threat, protection, avoidance, recovery, growth, reproduction, feeding, etc. — are further impaired. Signal gain on an already negative loop increases.
Physically moving at our sweet spot (>10 hrs/week) and eating what makes us feel best long-term makes it difficult to consume enough food in this case.
The reverse — calorie restriction paired with movement limitation — is the ironic mistake, and it is not symmetrical. Mechanical loading is what preserves muscle, strength, and aerobic capacity under an energy deficit. Remove the loading and keep the deficit, and the same shortfall now lands directly on tissue, with nothing buffering it. You lose the very capacity you would need to climb back out, and the metabolic system downshifts to defend (survival) what is left. Doing the opposite and expecting no consequence misreads which variable was protecting you.
Again, there is no biological workaround for a behavior constraint.
Re yesterday's post...
I'm not anti GLP-1
I am anti a society in which the only way we can maintain a healthy weight is via appetite suppression.
Of whatever form... GLP-1... keto etc.
How far are we going to take this?
As technology *advances* even further, and we basically only expend our BMR every day, do we just keep dialing up the strength of these drugs so that we keep eating less and less?
Humans were built as physical organisms - to move, to act on the physical world, expending energy.
We certainly weren't made to live on <2,000 kcal/d.