If you’re following the protocol and using the USPro 2000 at low setting there should be no heating. Are you in the study and reporting results and any problems?
I don't possess your extensive experience, Professor, and I readily acknowledge that. I applied ultrasound once a day for 3 weeks for my mom (Alzheimer’s) and dad (ALS) . It is true that I did not follow the full protocol. However, I have a valid reason for this. One of the reasons is, I experienced the painful response of the meninges to warming by ultrasound. I wanted to solve this problem with lowering energy and frequently changin the location on temps. The second reason was the tolerance I experienced same as the other neurostimulants. This should not affect your work because these are case sensitive subjects. However, if an insult has led to a destructive effect, I question whether our attempts to remedy this destruction will be truly effective without first clarifying what caused it. Without understanding the root cause, our efforts may be of limited benefit. While fitting a prosthesis to someone who has lost a leg is a reasonable solution, neurostimulation feels akin to flogging a lame horse; yes, the horse might run faster, but it doesn't address the underlying issue. I hold more optimism for your work on microtubules than I do for ultrasound therapy. Neurostimulation offers only temporary relief. Furthermore, beyond requiring application three times a day, ultrasound needs to be administered continuously during wakefulness. It stimulates rather than treats. Whether this overstimulation could lead to long-term depression is an area that warrants further research.