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@eXoZymes (Nasdaq: EXOZ) announced the achievement of a 100-fold scale-up of its N-trans-caffeoyltyramine (NCT) production process, demonstrating over 99% conversion from feedstock to product using its proprietary exozyme-based, cell-free biomanufacturing platform.
eXoZymes Inc. is a
@b2idigital Featured Company. See their full profile at
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The announcement validates the scalability of eXoZymes’ cell-free enzyme technology, proving that complex biocatalytic reactions can maintain exceptional efficiency at industrial volumes. The scaled production was executed under partner-operated conditions by Cayman Chemical using standardized protocols, demonstrating that the exozyme technology can be successfully transferred to and operated by manufacturing partners. This milestone also demonstrates that enzyme-driven systems freed from cellular constraints can overcome fundamental limitations that have historically hampered commercial biomanufacturing.
Several important competitive advantages were demonstrated by the announced breakthrough:
• 100× Scale-Up Success: The reaction scaled from laboratory to industrial volumes while maintaining performance, proving linear scalability of the exozyme platform
• Near-Perfect Efficiency: Over 99% conversion of feedstock to product achieved at scale, matching or exceeding small-scale conversion levels
• Partner Validation: Production executed by Cayman Chemical, confirming process transferability
• Cell-Free Advantage: Removing cellular constraints enables reliable, scalable production of molecules previously limited by traditional biomanufacturing
Michael Heltzen, CEO of eXoZymes, commented, “Scaling a complex biocatalytic reaction by 100× while sustaining high feedstock conversion strengthens our belief that exozymes will form the foundation of the next generation of biomanufacturing. We’re very enthusiastic about this progress and see it as an important inflection point in demonstrating that cell-free, enzyme-driven systems can be engineered to operate reliably at scale. This truly opens the door to producing molecules that have historically been constrained by traditional manufacturing approaches.”
Dr. Tyler Korman, CSO of eXoZymes, added further, “Achieving over 99% conversion at scale is a significant validation of our exozyme biosolution - both from a scientific as well as a commercial point of view.”
Read the complete announcement:
exozymes.com/blog/100x-scale…
eXoZymes is led by an experienced management team including Michael Heltzen, CEO; Damien Perriman, CCO; Dr. Tyler Korman, CSO and Co-founder; Dr. Paul Opgenorth, VP of Development and Co-founder; Fouad Nawaz, VP of Finance; Dr. Zachary Karl, Ph.D., VP of Business Development; Lasse H. Görlitz, VP of Communications; and Amy Lunzer, Chief of Staff.
To learn more about eXoZymes Inc., visit
exozymes.com. For investor inquiries, visit
exozymes.com/investor.
Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of
b2idigital.com/disclaimer.