The bellwether for housing supply is #Langford which is down 40% to 306 from 506 new homes. A combination of rising costs, softening sales & a more obstructive municipal council/admin are leading to declining housing starts. vrba.ca/news/housing-starts-… #yyj #bcpoli

A man being deliberately obstructive. Claims he has to get to a meeting, but keeps arguing & then gets arrested. If he wants to get to his meeting, he could have provided his details & then argued the case in court. Required to have a ticket for travel & show it on demand.

Chronic diseases like type 2 diabetes, cardiovascular disease, metabolic syndrome, obstructive sleep apnea, osteoarthritis, fatty liver/gallbladder diseases, and certain types of cancer.

This classic nebulization combo is most commonly used in Acute Exacerbation of Bronchial Asthma and also Acute Exacerbation of Chronic Obstructive Pulmonary Disease Why this combo works 1. Salbutamol Acts rapidly on β₂ receptors -bronchodilation - opens narrowed airways quickly. 2. Ipratropium Blocks muscarinic receptors -reduces vagal bronchoconstriction -further airway opening. Together they: - reduce bronchospasm - improve airflow -improve oxygenation -decrease work of breathing often within minutes

UCB BioPharmaceuticals the global biopharmaceutical company focuses on developing targeted small molecules and monoclonal antibodies for severe immunological and neurological diseases. However, UCB intersects with vaccination programs and clinical trials in several distinct ways: 1. Mandatory Vaccinations Required for UCB Drug Clinical Trials Because UCB manufactures potent immunomodulators and complement inhibitors, participants in their clinical trials (and patients taking their approved drugs) must strictly adhere to specific vaccination protocols. •ZILBRYSQ® (zilucoplan): This approved daily subcutaneous injection targets generalized Myasthenia Gravis (gMG). As a complement component 5 (C5) inhibitor, it significantly increases a patient's risk for life-threatening meningococcal infections. •The Trial/Treatment Rule: Clinical trial participants and patients must complete or update meningococcal vaccines (protecting against serogroups A, C, W, Y, and B) at least two weeks before receiving their first dose. If urgent treatment is required before the vaccine takes effect, they must receive prophylactic antibiotics. 2. Active Clinical Trials and Drug Pipeline UCB's clinical pipeline relies heavily on biologics, monoclonal antibodies (mAbs), and targeted small molecules rather than traditional vaccine platforms. Major active clinical trial areas include: •Neurology (Parkinson’s Disease): UCB is collaborating with Novartis to co-develop UCB0599. This is an oral, small-molecule alpha-synuclein misfolding inhibitor currently undergoing Phase 2 clinical trials to determine if it can slow disease progression. They are also testing UCB7853, an anti-alpha-synuclein antibody, in Phase 1 trials. •Advanced Immunology: In mid-2026, UCB closed a $2.2 billion acquisition of Candid Therapeutics, integrating multi-specific T-cell engager (TCE) antibodies into their pipeline. Their lead asset, cizutamig, is being evaluated to deplete pathogenic B-cells in severe autoimmune disorders. •Respiratory & Dermatology: UCB is evaluating galvokimig, a multi-specific antibody targeting IL-13, IL-17A, and IL-17F. It is currently in clinical testing for severe atopic dermatitis and is expanding into Phase 2a proof-of-concept studies for Chronic Obstructive Pulmonary Disease (COPD).

Been doing some code review research recently. My favorite obstructive PR Review patterns are: - Concern without Committment - Assertion without Explanation - Architectural pronouncement w/o guidance - Hedged requirement in question (quoted) - Pedantic style noise

High-risk rural patients were less likely than urban patients to be referred for obstructive sleep apnea evaluation in primary care in a new study presented at SLEEP 2026. Full study details here: hubs.li/Q04ltmq00 #SLEEP2026 #PrimaryCare #SleepMedicine #OSA #SleepApnea

Obstructive praying is dominance over the host nation. The prayers translate to threats against anyone that is not converted. The motto of Islam is convert or die and they openly proclaim that they want to colonize the world into a Caliphate under Sharia Law where the natives of the host nation are second class citizens. Look at the 57 nations that they have taken over and see what has happened to them. It is horrifying for women and children.

We just spoke with Dennis Hwang at #SLEEP2026 on: 👉Practical considerations that guide treatment decisions in OSA 👉A wearable waveband for capturing sleep in hypersomnia disorders 👉Obstructive sleep apnea, positive airway pressure therapy, and COVID-19 outcomes Stay tuned! @ResearchSleep @AASMorg #Neurology #NeuroTwitter

He's a paid sock puppet for the communists and Soros. He's a negative, obstructive and divisionary asshat.

I was diagnosed with severe obstructive sleep apnea last week. The doctor said if it was mild/moderate she could prescribe zepbound. Apparently I’m chunky but not chunky enough for it to be covered by insurance so now I have to use a cpap machine.

Ald. Lopez's rant against PBLs in committee, just before his ally Claudia Zuno announced her "remove obstructive bike lanes" candidacy, was one thing. But Lopez crossed a line when he said alders mourning fallen CDOT Planner Riley O'Neil are "privileged." chi.streetsblog.org/2026/06/…

@elonmusk ….to make an entire identity out of that guilt if any to be had, false profiling on purpose, that’s corrupt or obstructive justice, dirty, underhanded, rejecting, abandoning, disowning innocence, no respect for innocence neither the heart of truth, it’s man slaughter

Yes. Some Quota Jati race show a disruptive and obstructive mentality. Colonial British had included these Jati races in rigorous Criminal Tribes Act 1871 which continued well upto 1952. It is sad that Act was too harsh. SriHanuman.

Acute on chronic respiratory acidosis Acute exacerbation of Chronic Obstructive Pulmonary Disease * Severe asthma with ventilatory failure * Neuromuscular weakness * CNS depressant/drug overdose * Obesity hypoventilation syndrome

HbA1c 10%: This indicates average blood glucose ~240 mg/dL (13.4 mmol/L) over the prior 2–3 months (well into the diabetic range; >6.5% diagnoses diabetes). It reflects chronic hyperglycemia, which can be longstanding type 2 diabetes, new-onset diabetes, or rapid worsening of glycemic control. Icteric sclerae yellow skin color: These are classic signs of jaundice from hyperbilirubinemia (usually visible when total bilirubin >2–3 mg/dL). Icteric sclerae specifically point to bilirubin (not carotenemia, which spares the sclerae). This is typically obstructive (conjugated hyperbilirubinemia) when accompanied by pale stools/dark urine, elevated alkaline phosphatase/GGT, and dilated bile ducts on imaging. Icteric sclerae yellow skin color: These are classic signs of jaundice from hyperbilirubinemia (usually visible when total bilirubin >2–3 mg/dL). Icteric sclerae specifically point to bilirubin (not carotenemia, which spares the sclerae). This is typically obstructive (conjugated hyperbilirubinemia) when accompanied by pale stools/dark urine, elevated alkaline phosphatase/GGT, and dilated bile ducts on imaging. Suspect poorly controlled (or new/worsening) diabetes mellitus with obstructive jaundice, most classically due to carcinoma of the head of the pancreas (pancreatic ductal adenocarcinoma). Look for Courvoisier's sign (also called Courvoisier-Terrier sign or Courvoisier's law) is a clinical finding in which a patient with obstructive (painless) jaundice has a palpable, distended, and non-tender gallbladder. Diabetes can appear months before overt jaundice or other symptoms and is a recognized early warning sign. Cases often show: Initial presentation with hyperglycemia/HbA1c elevation (sometimes ~10% or higher). Followed shortly by jaundice and icteric sclerae. Workup/Evaluation: Liver function tests (bilirubin fractionated, ALP, GGT, ALT/AST), CBC, renal function, HbA1c confirmation, fasting/random glucose or fructosamine/glycated albumin (if assay interference suspected). Tumor markers (CA 19-9). Imaging: Abdominal ultrasound first → CT/MRI pancreas protocol or MRCP → EUS with biopsy if mass seen. Rule out other causes of jaundice (viral hepatitis serologies, autoimmune markers, etc.). This presentation is a classic "red flag" combination in medicine — especially in older adults with weight loss or painless jaundice — warranting urgent imaging to evaluate for pancreatic malignancy. Early detection improves resectability and prognosis. Bertoni M, Bertoni C, Abatangelo S, Scatizzi M, Lotti P. A Case Report of New-Onset Diabetes Mellitus as an Early Warning Sign of Pancreatic Ductal Adenocarcinoma in an Elderly Patient: The Earlier the Diagnosis and Surgery, the Better the Prognosis. Cureus. 2022 Nov 17;14(11):e31608. doi: 10.7759/cureus.31608. PMID: 36540459; PMCID: PMC9759095. pmc.ncbi.nlm.nih.gov/article…

Absolutely life changing for me. Clear as day just wow. Were you really bad before it? Ive had obstructive apnea my whole life so I was basically narcoleptic. If I ever sat down I would just pass out.

I haven’t felt like myself. I’m tired. Really tired & don’t feel good. I need the CPAP machine to come in to help with the sleep apnea. This process started in Dec. Diagnosed with Severe Obstructive Sleep Apnea but have to wait forever for the machine. I need to feel good again.

Trust me, we’re all still learning. 😊 The moment we stop questioning and discussing cases is the moment we stop growing as clinicians. Great catch considering tamponade—both are life-threatening causes of obstructive shock in trauma. 🩺🚑