Tier 2: Chronic health issues
-Cytokine panel.
-Th1/Th2/Th17 balance.
-24h urine n-methylhistamine.
-Anticcp / rf.
-24h urine prostaglandin D2.
-Fecal zonulin.
-24h urine leukotriene E4.
Then based on the results, you can further dial in your approach after you've covered the common lifestyle factors and conditions that exacerbate systemic inflammation.