Hashimoto's thyroiditis is the leading cause of hypothyroidism in iodine-sufficient areas of the world. It's quite on the rise, especially after COVID-19. So here are a few basic thoughts that might help you. Thread🧵

? Being skinny doesn’t treat Hashimoto’s thyroiditis

My mom is a big pharma patient for life by uhhh *checks notes* having Hashimoto’s Thyroiditis and getting Diabetes from it as a comorbidity. And she needs glasses, and an EpiPen. It costs way more than when I was on T lol

In other words, the vitamin B1 deficiency likely isn’t a contributor to the development of Hashimoto’s thyroiditis. Instead, vitamin B1 deficiency, in this case, is a consequence of the condition. As such, we can’t expect vitamin B1 to actually improve Hashimoto’s thyroiditis or the hair loss that occurs as a result.

Amazingly, that’s exactly what vitamin B1 did. In just a few hours to a few days, administration of B1 drastically improved the patients’ fatigue. The authors hypothesized that the autoimmune processes involved in Hashimoto’s thyroiditis may have resulted in a vitamin B1 deficiency, subsequently leading to a reduction in energy production and, thus, fatigue.

Interestingly, vitamin B1 might have relevance here, especially in the context of Hashimoto’s thyroiditis. In one case series, doctors administered vitamin B1 to 3 patients with Hashimoto’s thyroiditis. They hypothesized that vitamin B1 could help relieve one of the hallmark symptoms of low thyroid hormone: fatigue.

Vitamin B1, autoimmune thyroid disorders, and hair shedding: a possible connection? Autoimmune conditions that affect the thyroid – like Graves’ disease and Hashimoto’s thyroiditis – can have a domino effect on hair growth which is, in part, controlled by thyroid hormones. When these hormones get too high (i.e., Graves’ disease) or too low (i.e., Hashimoto’s thyroiditis), it can cause telogen effluvium – a form of diffuse hair shedding.

Today, it is the most common autoimmune disease, accounting for almost 30% of all autoimmunity worldwide. So Hashimoto’s is not rare. Depending on the population, 5–15% of women and 1–5% of men will test positive for thyroid peroxidase antibodies (TPOAb) in their lifetime, and a large proportion of those will eventually become hypothyroid. It is the leading cause of hypothyroidism in iodine-sufficient regions of the world, and its incidence continues to rise. Now an oversimplified definition of Hashimoto’s thyroiditis is that your immune system tags thyroid proteins like thyroid peroxidase (TPO) and thyroglobulin (Tg) as enemies, so, it will of course release antibodies that infiltrate the gland. But unfortunately, over time, this lymphocytic siege causes progressive loss of functional thyroid tissue → declining T4/T3 production → rising TSH → subclinical and eventually overt hypothyroidism.

It’s George. In 1912, Dr. Hakaru Hashimoto published a 30-page paper in German describing four middle-aged women with a strange new type of goiter: the thyroid was infiltrated by lymphocytes, formed true lymphoid follicles with germinal centers, showed fibrosis, and had peculiar large eosinophilic (Hürthle) cells. He called it “lymphomatous goiter”. The medical world in Europe dismissed it as an early stage of Riedel’s invasive fibrous thyroiditis and forgot about it for two decades. It wasn’t until 1931 (Hakaru died of typhoid fever in 1934) that American pathologists rediscovered the entity, and not until 1956–1957 when Rose & Witebsky reproduced it in rabbits and Deborah Doniach found anti-thyroglobulin antibodies in patients and asserted that they have an immunological reaction to human thyroglobulin. That’s when Hashimoto’s thyroiditis was finally recognized as the world’s first proven organ-specific autoimmune disease.

Diagnosis: 4th branchial pouch fistula (Pyriform sinus fistula) 🔥 When the child drinks, liquid passes through a congenital tract from the pyriform sinus in the pharynx and leaks out through the external opening on the neck. Classic presentation in kids! Can also present with recurrent neck infections or suppurative thyroiditis. Diagnosis confirmed with contrast swallow study or endoscopy. Surgical excision of the tract is curative.

Diagnosis: 4th branchial pouch fistula (Pyriform sinus fistula) 🔥 When the child drinks, liquid passes through a congenital tract from the pyriform sinus in the pharynx and leaks out through the external opening on the neck. Classic presentation in kids! Can also present with recurrent neck infections or suppurative thyroiditis. Diagnosis confirmed with contrast swallow study or endoscopy. Surgical excision of the tract is curative.

In Hashimotos Thyroiditis , with high titres of Anti TPO antibodies. ANA is raised most of the time

Hashimoto Thyroiditis vs Graves Disease

Clinical characteristics of patients with subacute thyroiditis and factors affecting development of hypothyroidism after subacute thyroiditis archivesofmedicalscience.com…