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Ivan Mindlin @ivan_mindlin
Joined October 2022
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Taking the momentum of our new-fresh-out-of-the-oven pre-print to fully move to BlueSky. Check the post to check the work: bsky.app/profile/ivanmindlin… See you there :)
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📢 Registration extension📢 Join us in the Embracing Complexity Workshop: Principled and Practical Approaches to Emergence! The workshop is scheduled for June 23-27 2025 at the Institute for Cross-Disciplinary Physics and Complex Systems in Palma de Mallorca, Spain 🇪🇸 👇👇👇
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Registration is open until April 25. No abstract is needed, but we encourage to submit (even with preliminary work 😉) More info at ifisc.uib-csic.es/en/events/… Registration HERE: forms.gle/eQhWYyC3mjd6EhYC9 Hope to see you there ☀️
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📢Paper out📢 “Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness” nature.com/articles/s42003-0… 👇Brief summary below👇 (1/8)

Whole brain modelling for simulating pharmacological interventions on patients with disorders of...

Communications Biology - Exploring virtual pharmacological treatments using whole-brain models and deep learning reveals improvements in disorders of consciousness models when stimulating...

nature.com
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In conclusion, our in-silico representation of patients hints that healthy-like brain dynamics might be recovered from DoC models through pharmacological perturbations, especially via serotonergic and opioid receptors, offering mechanistic insights into their effects. (8/8)
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Many thanks to @jdsitt and @ysanz6 for your supervision🧠, @ETagliazucchi and all the coauthors for the ideas and discussion 💪
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Interestingly, these shifts did not correlate with the receptor's similarity to structural connectivity but with the overall density of the receptor map. 5HT-2A receptors were more sensitive to perturbations. (7/8)
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Thank you @ysanz6 and @jdsitt for your supervision 🧠and @ETagliazucch and the rest of the co-authors for their contribution 🦾
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🚨First PhD preprint 🚨Here we propose a methodology for pharmacological treatment development of DoC. Our model suggests that high density receptors like 5HT2A and 5HT1A are the optimal to recuperate healthy-like dynamics in a DoC model. biorxiv.org/content/10.1101/…

Whole-brain modelling supports the use of serotonergic psychedelics for the treatment of disorders...

Disorders of consciousness (DoC) are a challenging and complex group of neurological conditions characterised by absent or impaired awareness. The current range of therapeutic options for DoC...

biorxiv.org
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Many many thanks to the team and to @ysanz6 and @jdsitt for their guidance in this project 😁
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