Developing transformative therapies for Type 2 Diabetes @fractylhealth | X opinions/posts are my own.

Joined May 2013
Photos and videos
Jay Caplan retweeted
As the speaker stated today … “my most important slide”. #ADA2026.
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Jay Caplan retweeted
Diabetes researchers ejected from conference after criticizing White House. The editor of ADA journal Steve Kahn was nondisruptivedly handing out his recent editorial in ADA journal that criticized Trump NIH policies. Big mistake by @AmDiabetesAssn washingtonpost.com/health/20…
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Jay Caplan retweeted
I grew up in apartheid S Africa, where muzzling of speech and encroachment on academic freedom were the norm. I came to the US to pursue a career in science. I never thought that at this stage of my career, I would ever experience my youth again. #StandUpForScience #ADA #ADA2026
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Jay Caplan retweeted
Looking forward @DDWMeeting. Exciting parts of #DDW is seeing innovative technologies that have the potential to truly change patient outcomes Check out @FractylHealth Duodenal Mucosal Resurfacing (DMR) — science, actual procedure, and what lies ahead in metabolic endoscopy
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RT @ScottGottliebMD: My essay in the Sunday Washington Post: “A viral infection can have devastating effects. I experienced this firsthand.…
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Jay Caplan retweeted
Joel Habener @MassGeneralNews @Harvard at one of the lab social gatherings in the mid 1980s with one of the labs talented research fellows, currently the President of @Penn Larry Jameson
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro ⁦@MassGeneralNews⁩ ⁦@TheEndoSociety⁩ ⁦@Harvardwsj.com/health/pharma/joel-h…
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Jay Caplan retweeted
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro ⁦@MassGeneralNews⁩ ⁦@TheEndoSociety⁩ ⁦@Harvardwsj.com/health/pharma/joel-h…
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Jay Caplan retweeted
📉 Our comprehensive review of Medication Adherence published in @DiabetologiaJnl Non-adherence affects ~38% of people T2 diabetes, Leads to higher HbA1c, more micro/macrovascular complications, hospitalisations, mortality, and major healthcare costs. 🔍 Causes span patient, socioeconomic, condition-related & system factors. 💊 Effective strategies: pharmacist-led care, fixed-dose combinations, and tailored, multifaceted interventions. Tech & motivational tools show mixed results. 🔑 Personalised, scalable solutions are urgently needed. #T2D #DiabetesCare #MedAdherence Led by Patrick Highton link.springer.com/article/10… With @mark_funnell @PankajLeicester @LeeLingLim1 @scelee1 @frazac
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RT @ScottGottliebMD: 12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine…
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Jay Caplan retweeted
Fantastic @DKThomp podcast with Drs. @seeleyrj and David Alessio (@DukeMedSchool) on #GLP1 - what they do, how, & current thinking on why they have such broad effects on metabolism & inflammation. podcasts.apple.com/us/podcas…
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Jay Caplan retweeted
Replying to @harithr
Honored to join the Board of Fractyl Health at such a pivotal moment. Revita® is advancing through late-stage development, and Rejuva® is preparing for first-in-human studies. Fractyl is redefining how we treat obesity and type 2 diabetes by addressing root causes, not just symptoms. Excited to help shape this next chapter.
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Jay Caplan retweeted
Welcoming @MetabolicEndo and Ian Sheffield to our Board marks an important moment for Fractyl. Their expertise in pioneering new approaches to obesity care and in building healthcare businesses with lasting impact will help guide us through this next stage of growth. I’m also grateful to Amy Schulman for her service and leadership on our Board, and for helping position Fractyl to seize the opportunities ahead. Looking forward to the journey as we continue advancing Revita® and Rejuva® toward our goal of transforming metabolic care. $GUTS #FractylForward Revita® is for Investigational Use Only in the U.S. under Federal law. Rejuva® is in preclinical development and has not yet been assessed by regulatory agencies.
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Jay Caplan retweeted
Happy special birthday to my friend and colleague the incomparable Jens Juul Holst @UCPH_Research @Metabolcenter @EASDnews @uni_copenhagen @novonordiskfond
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Jay Caplan retweeted
28 Jul 2025
For the rest of July, folks in the UK get 25% off when they preorder Food Intelligence (my book with @juliaoftoronto) at @Waterstones. waterstones.com/book/food-in…
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Encouraging my Canadian endocrine colleagues to read this and at least inform themselves. .
Canada's media continues to ignore the scandal of paediatric gender medicine. Journalists echo activist misinformation and show no curiosity about one of medicine's greatest crimes. My formal complaint to @globeandmail, signed by 41 Canadian physicians. macdonaldlaurier.ca/far-too-…
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Jay Caplan retweeted
Canada's media continues to ignore the scandal of paediatric gender medicine. Journalists echo activist misinformation and show no curiosity about one of medicine's greatest crimes. My formal complaint to @globeandmail, signed by 41 Canadian physicians. macdonaldlaurier.ca/far-too-…
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Jay Caplan retweeted
22 Jun 2025
#ADA2025 🚨 One-shot #GLP1 gene therapy 🧬🚨 Single AAV dose into pancreas cut weight & glucose in obese mice — nutrient-triggered GLP-1, no injections needed 🐁 DIO mice:  • −20% BW @ wk3  • −32% BG @ wk5 🥣 ↓ food intake 🧠 GLP-1 only secreted when fed ✅ No hypoglycaemia ⚠️ No human data yet 🧪 EU trial (RJVA-001) starts 2026 Big potential, big unknowns 📌#1970-LB poster | Sunday #ADA2025 #GeneTherapy #SmartGLP1 #T2D #Obesity #GLP1
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