That's disturbing, but not shocking. Unfortunately, some scientists choose not to publish results that contradict their preferred narrative or could harm their career prospects. Science is about discovering the truth, not advancing individual careers.

Today we celebrate and say farewell to outstanding postdoc, Aleksey, as he moves on to the next stage of his career. Thank you for your hard work and contributions to the lab. It has been a pleasure working with you. We wish you every success!

The wait is almost over. Next week the complete dataset from the largest mTOR modulator screening project will go live in the Longevity Intervention Database (LID). In partnership with @OraBiomedical and our great sponsors we have completed a rapid lifespan analysis of 601 mTOR modulators in roundworms. Our goal in open-sourcing this foundational data is to allow AI, labs, researchers and companies to accelerate progress and move the longevity field forward. Many more screening projects will be launched by the Rapamycin Longevity Lab (@omipalRLL) in collaboration with Ora Biomedical and others. But today I wanted to give you a sneak peek at the updated leaderboard. Here are my three key takeaways from this new phase of data: 1⃣ We have more than doubled the number of compounds beating Rapamycin. In our first phase, we identified 5 compounds that outperformed the best recorded Rapamycin baseline (27% median lifespan extension). With this second release we now have 11 compounds sitting above the red line. 2⃣ 24 new compounds qualified for the top list. It is fantastic to see these new entries. It will be incredibly interesting to dig deeper into the data to understand how they target the mTOR pathway in different ways. More to come on this. So stay tuned! 3⃣ Omipalisib continues to be a standout compound. The Rapamycin Longevity Lab was the first to discover its lifespan-extending properties in worms. We have conducted and are currently conducting experiments across multiple species to see if we can translate these results beyond worms. We are also evaluating combination therapies to see if we can enhance the longevity effects even further. If you are a researcher or organization interested in collaborating either to support upcoming screening projects or to validate any of these top-performing compounds in other strains then please reach out. Let’s collaborate and move the field forward together! And big thanks to all who have helped out with all the work so far!

Not My Party, But One of the Good Ones: Emily Cox and the Shifting Politics of Brandwood & Kings Heath open.substack.com/pub/mikeol…

IT director wrongly kept in a cell to be paid £34,000 compensation mol.im/a/15746945 via @DailyMail

RT @MHNWitchfinder: Hertfordshire Police Pay £34,000 to Samuel Collingwood Smith Police have admitted wrongful arrest and imprisonment and…

RT @MHNWitchfinder: Hertfordshire Police Pay £34,000 to Samuel Collingwood Smith Police have admitted wrongful arrest and imprisonment and…

Labour creep in front of Lib Dems in Brandwood and Kings Health, Greens remain in 4th place

Our Rapamycin & Exercise clinical trial has just been published! The topline result? Rapamycin didn't help. Instead, it may have made things worse. Here's what we found 🧵 onlinelibrary.wiley.com/doi/…

Policheck predict Lib Dem victory in Brandwood and Kings Heath. I have been canvassing there. I don't think the Reform support is as high as Policheck predict.

Wrongful WhatsApp arrest police threw man in a cell over blog post mol.im/a/15685053 via @DailyMail

Aging may or may not be classified as a disease, but that’s largely semantics. What matters is that aging is a malleable, targetable biological process, and slowing human aging would result in massive health benefits.

Three weeks of Operation Epic Fury. The Joint Force owns the skies, but Tehran holds the Strait. Additional U.S. fighter aircraft and naval assets arrived in both theaters, and Marine expeditionary forces are en route. 8,000 Iranian targets and 130 ships struck, per CENTCOM.