The Journal of Physiology publishes original research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms
Joined November 2010
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Hollie Speer (@UC_RISE) and colleagues detail a study protocol using a #microdialysis technique to investigate skeletal muscle reactive oxygen species and microvascular #endothelial function in age-related #hypertension 🔎 💉
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'ESM-1 and GBP-1 are associated with endothelial dysfunction: emerging #biomarkers or key players in the pathophysiology of #preeclampsia?'
Read the review from Ines Pronk (@umcg) and co-authors ✍️ 📜
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'The #LINC complex in blood vessels: from physiology to pathological implications in #arterioles' 🫀 🔎
In this review, Gonzalo Ferreira (@fmedoficial) and colleagues elucidate the LINC complex's role in health and disease 📜
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Abigail R. Byford (@UoL_LICAMM) and colleagues investigated endothelial-to-mesenchymal transition in the #fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational #diabetes 🔬 🔎
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In this study, Fernanda Sanhueza-Olivare (@uchile) and colleagues performed vascular remodelling in a mouse model of heart failure with preserved ejection fraction💻️ 🫀
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Ignacia González & Rodrigo Maldonado-Agurto (@ufinisterrae) examine the role of cellular #senescence in #endothelial dysfunction and #vascular remodelling in arteriovenous fistula maturation 🫀 🔬
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'Dysregulation of #neural tube vascular development as an aetiological factor in autism spectrum disorder: Insights from valproic acid exposure'🫀
Read the review by Jorge Manzo (@UVeracruzanaMx) and colleagues 👇️
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Ameyalli Gómez-Ilescas and Patricia Pelufo Silveira (@mcgillu) examine early adversity and the comorbidity between #metabolic disease and #psychopathology ✍️ 🧠
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'Metabolic heterogeneity of endothelial cells: potential for tissue-targeted therapies in diabetic vascular complications'
Aryan Y. Sarnaik examines the work of McAleese et al. (2026) in this #JournalClub article ✍️
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Yifeng Dai (@umcg) and colleagues examined the differential effect of #lead and #cadmium on mitochondrial function and NLRP3 inflammasome activation in human #trophoblast 🔬 💉
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'Reducing the negative effects of calciprotein particles on endothelial cells in chronic kidney disease: A promising non-pharmaceutical approach'
Stephanie Lapierre-Nguyen & Jigar Gosalia (@CUAnschutz) examine the work of Feenstra et al. (2026) ✍️
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'Pathophysiological features of pre-clinical HFrEF and HFpEF models'
Alexa N. King (@uofg) examines the work of Méndez-Fernández et al. (2026) in this #JournalClub article ✍️
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In this study, Lian Feenstra (@umcg) and colleagues observed that calciprotein particle-induced #calcium overload triggers #mitochondrial dysfunction in endothelial cells 🧫 🔬
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'Macrophage lipid accumulation and inflammation: How aquaporin 3 regulates metabolic adaptation to palmitic acid in cardiometabolic diseases'
Mariana Camões (@UnivdeCoimbra) et al. examine the work of Luévano-Martinez et al. (2026) ✍️
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'The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial #endothelial cells altered by gestational #diabetes mellitus' 🔎
Read the #research from Silvija Tokic (@MedUniGraz) et al. 👇️
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In this review, Macarena Lépez (@FacMedicinaUC) and colleagues examine the impact of maternal #obesity on fetal #myeloid immune cells and explores potential mechanisms that underlie early-life immune programming 🔬 📜
Read it here👇️
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'Methodological evaluation of muscle oxidative stress in normotensive and hypertensive individuals: Ageing-related'
João Pedro Floriano and Alisson Luiz da Rocha (@usponline) assess the work of Speer et al. (2026) in this #JournalClub article ✍️
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In this review, Amanda A. de Oliveira (@UAlberta) and co-authors discuss excessive #hypercholesterolaemia during #pregnancy as a risk factor for endothelial dysfunction in pre-eclampsia 🔎 🔬
Read it here👇️
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'Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment #epithelial cells with #hypertensive phenotype' 🫒 🧬
Read the #Research by Álvaro Santana-Garrido (@fafarsevilla) and colleagues here👇️
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#Research by Esthefanny Escudero-Guevara (@ubbchile) et al. identified that #stroke severity shapes extracellular vesicle profiles and their impact on the cerebral #endothelial cells 🧠 🔬
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