Elmore, Ahern, @BMLevitan, Satin et al. @universityofky shed light on RRAD, a protein that helps regulate calcium channels in the heart. They find its tail region is crucial for both attaching to the cell membrane and influencing heart function. hubs.la/Q02Gm3H60
Today's program enrichment was quite special-- we went on a clinical facility tour @UK_HealthCare ! But before that, we listened to some incredible cardiologists talking about their medical career journey.
@Kentucky_Cards@GillKentucky
Awardee spotlight of the day⭐️
@Diksha_Satish13 examines the lipid droplet accumulation in different APOE genotypes at @LJohnsonLab. Her favorite part of the project is to image & observe the cell transformation. Fun fact: her last name is actually her dad's first name!
@UKUGR
Today we had @LJohnsonLab sharing about his journey from being a journalist to becoming a PI. For awardees presentation, David presented his inner aortic fluid velocity model while James shared about his SARS-COV-2 antibodies project!
@UKYMedicine@ukyengineering
Awardee spotlight of the day💫
@krka2008 studies the effect of exenatide on circadian rhythm of diabetic mice at Dr. Zhenheng Guo's lab. She's also interested in the structure of brain & hopes to become a psychiatrist. She's originally from Ukraine!
@UKUGR
Awardee spotlight of the day ⭐️
Jena Malone studies the effect of opioid on renal functions at @Dr_Analia_Loria lab. She wants to combine her passion for problem solving and laboratory techniques to work as a forensic scientist in future!
@UKAgriculture@ResearchKY
Our second lunch enrichment kicked off today! Current @uky_mdphd students shared about their research & application experiences. Patience & knowing why you do what you are doing are the key. Among the presenters, @GregMilburn4 was in our program back in 2018!
Congratulations @GillKentucky on your participation!
Promising findings that will pave the road for a first-in-human clinical trial to test the efficacy of this novel gene therapy in pts with ischemic cardiomyopathy.
SIMPLY WOW!
Read details here:
ahajournals.org/doi/reader/1…
#JADEL
Don't you love it when your cardiac sonographer is recognized for their outstanding skills & efforts?
Its not easy to echo tiny mouse hearts. 😄
Way to go @BMLevitan.
Keep up the great work!
@ASE360@CASEfromASE
Impressive reduction in post-MI size:
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/153/…
Ahern et al show that in the absence of Rad, myocardial L-type calcium current is greater at peak, balanced by faster decay to yield no AP prolongation. Rad KO supersedes beta-adrenergic receptor signaling to the LTCC to enhance trigger Ca & heart function bit.ly/3BbIJL1
Admit it! Some basic science work is more cool than others:
m.jbc.org/content/early/2019…
Take 5 & read how we engineered a sustained increase in inotropy & faster lusitropy without any adverse effects common with other inotropic Rx.