Joined September 2014
- Tweets 543
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- Followers 1,670
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32 Photos and videos
Pinned Tweet
20 Dec 2024
Listen to "Code Green or Code Greed? Dr John Kellum" by The Critical Care Commute Podcast creators.spotify.com/pod/sho…
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John Kellum retweeted
Apr 16
Remote Ischemic Preconditioning: Is This Star Still Rising?
bit.ly/4crPbAV (FREE)
@kellumja @DanaFuhrman4
ALT Proposed mechanism of action for remote ischemic preconditioning. Multiple mechanisms for remote ischemic preconditioning have been suggested. A novel mechanism of action shown here involves high-mobility group Box-1 (HMGB-1) and possibly other molecules, released from muscle in response to transient ischemia. Transcriptomic imprinting of renal tubular epithelial cells occurs following signal transduction from engagement of HMGB-1 with Toll-like receptor 4 (TLR-4) on proximal tubular epithelial cells.
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Mar 31
Somehow I missed this review from last March. Obviously, I think it's spot on!
Book Review: Code Green How the Big Lie in Healthcare Affects Us All by Kellum John - PMC share.google/OAuZO0Zgwb8wFGw…
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1 Nov 2025
How is possible that ICU physicians still believe that serum creatinine quantifies kidney function when nephrology adopted eGFR 20 years ago? How is it OK that a woman must lose 2.5x as much kidney function as a man just to get 1 SOFA point for renal? jamanetwork.com/journals/jam…
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15 Oct 2025
Another tripute to a giant in our field. Rest in peace dear brother. sciencedirect.com/science/ar…
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15 Oct 2025
Impact of propofol or sevoflurane on the renoprotective effect of remo... sciencedirect.com/science/ar… --This is a fascinating story. RIPC seems to work in some trials but not at all in others. Two big trials were negative so that's the end of story right? Not so fast. . .
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15 Oct 2025
...It turns out that the big trials used propofol and there is body of evidence showing that this agent blocks the protective effect of RIPC. Now with this paper we show how. Propofol interferes with the release of TIMP-2 and IGFBP7 from the kidney in response to RIPC...
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15 Oct 2025
TIMP-2 and IGFBP7 are stress markers for the kidney, no stress, no protection. Now the stage is set to do a large trial of RIPC using sevoflurane anesthesia and better yet we can also titrate RIPC to biomarker response. Precision medicine at its finest!
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11 Oct 2025
Funny thing. . . 7% of patients with sepsis have "Nephrons of Steel" and don't develop Acute Kidney Injury when by all accounts they should. These "AKI-resistant" humans may hold the key to AKI prevention and therapy. doi.org/10.1186/s13054-025-0…
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12 Aug 2025
After more than 5 years and nearly 15,000 patients screened, main results from Tigris are out! Precision medicine isn’t for the faint of heart! PMX Hemoadsorption to remove endotoxin is highly effective in this very select population globenewswire.com/news-relea…
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14 Jun 2025
Learn why sepsis criteria are grossly inadequate for capturing Kidney dysfunction. Https://rdcu.be/eqH2N
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26 Mar 2025
As seen in other studies, about half of all patients admitted to the ICU develop AKI with about 2/3 stage 2-3. However only 12% of stage 2-3 are have persistent severe kidney dysfunction. Outcomes for these pts are far worse. Endpoint for drug trials?
rdcu.be/eebnP
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20 Mar 2025
doi.org/10.1016/j.jacc.2024.…
FACTCHECK “SGLT2 inhibitors result in “AKI” using KDIGO definitions yet confer undisputable benefits across a variety of settings.” FALSE
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20 Mar 2025
Check out table 4. AKI rates were not different across study arms with the exception of DAPA-HF trial in which serious kidney events were actually less common with dapagliflozin compared to placebo (P=0.009). The claim that SGLT2 inhibitors cause AKI is demonstrably FALSE.
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18 Nov 2024
See et al. Makes a compelling Argument for Clinician Autonomy, and Individualized Care in the ICU. journals.lww.com/ccmjournal/…
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10 Nov 2024
We will never achieve our aspirations for a truly equitable society until those born into privilege see progress in absolute terms not just relative to people they believe they are superior to.
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23 Oct 2024
Kicking off Critical Care Nephrology precourse @ASNKidney week with Michael Connor. Thanks to course directors Ashita Tolwani and Mark Perazella
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17 Oct 2024
I think I struck a nerve with the comparison to social media :-). But really how can @ORCID_Org be a trusted source for information if they take no responsibility for what is in their database?
11 Oct 2024
This way, we can hold our member organizations accountable for adding only true and valid data to the ORCID records they have been granted permission to by the record holder.
Data that you have added yourself can never be removed by third parties.
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