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Lori Passmore @lapassmore

Molecular biologist. Group Leader @MRC_LMB. Fellow @clarehall_cam. Optimist. (she/her) Views/opinions are my own.

Joined January 2015
  • Tweets 1,277
  • Following 790
  • Followers 5,026
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I am no longer actively using this account. Please find me on the other place. 🦋
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We have an open #postdoc position to study the molecular mechanisms of #DNArepair !🧬🔬 The project will build on recent findings nature.com/articles/s41586-0… and established collaborations, using #cryoEM and #SingleMolecule imaging. Access to fantastic facilities @MRC_LMB .

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions

Nature - FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the...

nature.com
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Come join the amazing members of my team 🤩🤩!
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Lori Passmore retweeted
Pilar Cossio@PilarCossio2
23 Oct 2024
CryoEM community: we encourage you to submit applications to the Almeida Award #cryoEM BPS subgroup:
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I presented this work at #EESRNA @embl @EMBLHeidelberg An amazing meeting organised by @LabConti @OlivierDuss @torbenheick and Karla Neugebauer!!
Lori Passmore@lapassmore
20 Oct 2024
New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
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Unfortunately I had to leave the conference very suddenly and unexpectedly due to a family emergency. I really missed meeting and speaking with so many people. Many apologies - I would be happy to zoom meet with anyone who wants to chat - please drop me an email!
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New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
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The enzymatic machineries of gene expression (deadenylation complexes, RNA polymerases) are highly conserved. .... but the evolutionary plasticity of IDRs found in a multitude of regulators (RNA adaptors, transcription factors) allows rewiring of gene expression programs. 10/
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Preprint here: biorxiv.org/cgi/content/shor…

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Great fun with the @RappsilberLab ! Photo-crosslinking improves the contrast of crosslinking mass spectrometry.
Francis O'Reilly@FJ_OReilly
11 Sep 2024
New preprint! We show that photo-crosslinking dramatically improves structural insights into protein complexes compared to traditional crosslinking MS methods. biorxiv.org/content/10.1101/…
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Very cool structure!
conti_lab@LabConti
10 Oct 2024
Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇
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I am really looking foward to working with @SjorsScheres as Joint Head of Structural Studies @MRC_LMB !
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