1/4) There is a peptide proven in human randomized controlled trials to help protect against “leaky gut.” It’s called: larazotide. But the implications may go far beyond bloating. There’s also emerging evidence for autoimmune disease (T1D, RA), and even long COVID. Briefly, here’s how it works. Your intestinal lining is held together by proteins called tight junctions. Think of them as the mortar between bricks. In response to gluten, bacteria, and inflammatory triggers, the gut releases zonulin, which opens those tight junctions and increases intestinal permeability (“leaky gut”). Larazotide blocks this process by binding the zonulin receptor before zonulin can.

This one finds that multi-marathoners not only exhibit substantially higher V̇O2max values than population norms across all age groups, but they also show a more gradual age-associated pattern in V̇O2max and a 3.7% reduction in estimated all-cause mortality per 1 mL/kg/min increase in V̇O2max.

📺 TV en DIRECTO | Así ha sido el espectáculo de luminoso en homenaje a Gaudí para inaugurar la nueva torre de la Sagrada Familia social.elpais.com/svq5s

The Inconvenient Truth About the Blue Zones and Longevity The world's longest-lived places aren't quiet villages with good diets. They're wealthy, educated cities with strong healthcare — and even they hit the same biological wall. By @biogerontology forever.ai/p/the-inconvenien…

JUST IN: Florida hospital reveals Palantir software has cut sepsis deaths by more than half since it was installed.

Unlike in sleep deprivation, the muscle atrophy caused by caloric restriction affects both slow twitch and fast twitch muscle fibers.

Every few months, a new therapy arrives with the same promise: activate this pathway, inhibit that enzyme, filter your blood, flood your cells with light, and the clock of aging will slow. NAD precursors, senolytics, mTOR inhibitors, plasmapheresis, ozone infusions, methylene blue… The list grows longer, the marketing grows louder, and the evidence, the actual human evidence, stays stubbornly thin. Walk into most longevity clinics today and the experience is carefully constructed. Red light panels. Cold plunges. IV drips. Expensive diagnostics. Physicians positioned as pioneers. It looks sophisticated. It feels scientific. It costs a great deal of money…. But here is the uncomfortable question nobody in this space wants to ask: are we actually improving human longevity, or are we stacking interventions on top of a poor understanding of human physiology? substack.com/@inigosanmillan…

Retatrutide isn't supposed to be everywhere. Touted as the next generation in the GLP-1 craze, it's an experimental weight-loss drug that is not authorized outside of clinical trials. The Food and Drug Administration hasn't reviewed whether it is safe and effective, which is the legal path for prescription drugs to come to market. And yet retatrutide is for sale all over the internet, a phenomenon with no modern precedent. @adamyamaguchi

This is huge for diabetes and obesity treatment. "Researchers tested a new once-daily oral GLP-1 drug called elecoglipron and found it produced substantial reductions in both blood sugar and body weight in Phase 2 trials." "In people with type 2 diabetes, the highest dose reduced HbA1c by up to 1.9 percentage points and lowered body weight by 7.7%." "In adults with obesity or overweight, participants lost up to 11.8% of their body weight after 36 weeks, with weight loss still continuing at the end of the study." The most exciting part is that elecoglipron is a pill, not an injection. If larger Phase 3 trials confirm these results, highly effective obesity and diabetes treatments could become far easier to prescribe, distribute and use worldwide. We may be entering an era where powerful metabolic medicines no longer require injections.

Crumbl needs to be stopped. Their new "dirty soda" contains 186 grams of sugar, the equivalent of eating 19 Krispy Kreme donuts. This is a metabolic disaster and should be illegal. Please do not drink this.

Here, increased insulin resistance as indicated by a lower estimated glucose disposal rate (eGDR), an index of insulin resistance, was associated with an increased risk of cancer in US adults and this relationship was partially mediated by systemic inflammation, as indicated by the neutrophil-to-lymphocyte ratio (NLR), a simple and effective marker of inflammation and immunity, and the neutrophil percentage-to-albumin ratio (NPAR), an inflammatory indicator defined as the percentage of neutrophils divided by the concentration of albumin.

🚨I Investigated Retatrutide's Biggest Unknowns (127 Biomarkers) 1/7) I set out to investigate some of Retatrutide's biggest unanswered questions and paradoxes. 🤔Why do some people seem to get hungrier on reta? 💪Could it actually be muscle-sparing? (for some people) 🩸And what is it doing to cholesterol that's different from other GLP-1 drugs? Today’s letter breaks it all down (link at the end). And I promise you, there are some insights here that you almost certainly haven't heard before. #reta #peptide #glp3 #staycurious

Medium-chain triglycerides (MCTs) punch above their weight. Unlike long-chain fats that take a circuitous route, MCTs head straight from gut to the liver, rapidly fueling ketone production and improving glucose control, satiety, and energy metabolism—often with just 10–20 g/day. Emerging evidence also points to benefits for heart function, with effects varying by chain length. #Metabolism #Nutrition #CardiovascularHealth cell.com/trends/endocrinolog…

This one indicates that the improvement in cardiorespiratory fitness with endurance exercise training is influenced by sex and that the degree of cardiac remodelling with training in previously sedentary adults is neither different between sexes nor impaired by having a smaller pre-training left ventricular end-diastolic volume.

Alexander Zverev is living on needles for the last 25 years...taking Insulin everyday since age 4. Today at 29, he became a GRAND SLAM CHAMPION. Overcame a life nemisis. Huge Inspiration to children with diabetes. He runs a foundation for the same 👏

Bigger picture... Folks are coming at @bryan_johnson for being "fragile." I see it differently. I see someone who is highly conscious of stress. That is, aware of the cost of stressors and deliberate about where he spends his stress budget - his adaptation reserve (alancouzens.substack.com/p/w…) Most people don't spend that budget consciously. They spend it on poor sleep, excess alcohol, chronic stress, unhealthy relationships, endless doom-scrolling, and a hundred other withdrawals that quietly accumulate into health debt. Whether it's financial health or physical health, the first step is the same: A brutally honest awareness of reality.

I was a professional tennis player. I competed at Wimbledon. I was ranked 117 in the world. At 52 I was still playing competitive singles multiple times a week. I was the fittest person in most rooms I walked into. I had a heart attack on a tennis court. I used to think fitness was a shield. If you exercise hard enough, eat reasonably well, and keep your weight down, heart disease cannot touch you. I was wrong. And the data says I am not alone.

Physical activity and metabolic rates in humans "we also review the evidence, mostly from humans, that increased levels of physical activity slow aging and reduce vulnerability to disease by diverting energy away from processes that improve reproductive success at the expense of long-term health and by increasing energy allocation to repair, maintenance and capacity building." journals.biologists.com/jeb/…

Maturing is realising these mf's do more harm than good.

One of my favorite happy places 🙌