Structural biologist and biochemist @HelmholtzMunich. PhD from @Hopfnerlab @GeneCenter_LMU | CryoEM, crystallography and all that jazz 🎼

Joined February 2018
Photos and videos
Marijke Jansma retweeted
Excited to share our new study with the Müller and @SchullerJm labs, online @nature: nature.com/articles/s41586-0… This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of the enzyme HDCR 🍩 1/🧵
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We are thrilled to share more information about our speakers for the #Postdoc Meet & Mingle on June 29th next week!😍 Dr. Christian Linke-Winnebeck, Principal Scientist @ChromoTekGmbH will open the evening program with a talk about his career path & #alpacas:
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Marijke Jansma retweeted
Hello to all the postdocs in Munich! We are now on your favorite social media site 😎
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Marijke Jansma retweeted
Transcription-coupled DNA repair: After a long journey, we can now see how CSA, CSB, UVSSA and CRL4 remodel the transcribing Pol II complex for ubiquitination and DNA repair. Masterpiece by @KokicGoran. nature.com/articles/s41586-0…
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Marijke Jansma retweeted
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
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Marijke Jansma retweeted
Today we released a preprint biorxiv.org/content/10.1101/… where we take a step towards the next challenge: building a nanopore single-molecule PROTEIN sequencer! 😳 Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, augmented with MD simulations of @aksimentievLab 1/x
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Very shocking numbers, but hardly surprising :( #AcademicMentalHealth
Marijke Jansma retweeted
My Emmy Noether Program funded research group is starting this summer at the Institute of Virology, @TU_Muenchen! Thanks to @dfg_public, I am now looking for PhD students interested in antiviral immunity and NTase enzymatic mechanisms! Please RT web.med.tum.de/fileadmin/w00…
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Marijke Jansma retweeted
Excited to share the inaugural lab paper. Thanks to @AutomneNine @RDasLab @ramyarangan and Twitter-less Marike, Adam and Kathy, also @NogalesLab. We not only obtained an atomic structure of human telomerase but also discovered histones bound to telomerase RNA.
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Marijke Jansma retweeted
Internationally, we the Dutch are seen to be direct and blunt. Our checklist for travel to the Netherlands lives up to that reputation.
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Marijke Jansma retweeted
He seems like a very happy old man looking forward to a bright and wonderful future. So nice to see!
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Marijke Jansma retweeted
People should stop calling SARS-CoV-2 mRNA vaccines a ‘miracle’. These vaccine are not miracles—they did not drop out of the sky. These vaccine are the result of decades of basic research. Everyone who likes the idea of vaccine miracles should support funding for basic research.
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Marijke Jansma retweeted
In a major scientific breakthrough, the latest version of #AlphaFold has been recognised as a solution to one of biology's grand challenges - the “protein folding problem”. It was validated today at #CASP14, the biennial Critical Assessment of protein Structure Prediction (1/3)
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Happy to see the result of our lockdown project online! Check out our review on the large kinases that signal DNA damage:
16 Nov 2020
High resolution cryoEM allows unprecedented structural insights into the large apical kinases (ATM, ATR and DNA-PKcs) that orchestrate the DNA damage response. Enjoy our recent review by Marijke @marijkroscope and Karl-Peter #cryoEM #DNArepair doi.org/10.1016/j.pbiomolbio…
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After resubmitting the manuscript, several exciting higher resolution structures of DNA-PKcs and ATR were published. For further reading on the activation mechanism of these kinases, please also check out doi.org/10.1101/2020.10.19.3…

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Marijke Jansma retweeted
“My wish is that this will provide a positive message to the young girls who would like to follow the path of science, and to show them that women in science can also have an impact through the research that they are performing.” - 2020 Chemistry Laureate Emmanuelle Charpentier.
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