Professor at MIT, Surgeon-Scientist. DNA damage signaling, protein kinases, precision cancer medicine, signaling in tumor microenvironment
Joined September 2009
- Tweets 138
- Following 129
- Followers 906
- Likes 133
4 Photos and videos
Michael Yaffe retweeted
9 Feb 2025
Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science better!
54
71
657
122,272
8 Oct 2024
Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!
3
22
1,914
8 Oct 2024
Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - cell.com/cell-reports-medici…. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!
6
18
103
7,483
29 Jul 2024
nature.com/articles/s41587-0…
Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.
2
11
1,051
Michael Yaffe retweeted
29 Jul 2024
This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.
28
333
1,788
131,437
9 May 2024
Thrilled to share our characterization of the human tyrosine kinome.
Try out the public website: kinase-library.mit.edu/home
Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson!
nature.com/articles/s41586-0…
4
43
158
16,120
6 Apr 2024
This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.
1
16
1,208
6 Apr 2024
1
4
643
20 Jul 2023
Excited to share our latest story - JNK and Erk MAPK signaling controls senescence from damaged replication forks, and at later times drives the SASP. Means MEK inhibitors with topoisomerase chemo likely to be a bad combo!
2
6
45
6,196
24 Jun 2023
Fantastic motifs and signaling meeting at EMBL the last 2 days in honor of Toby Gibson.
6
37
3,562
Michael Yaffe retweeted
9 May 2023
Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between @genophoria, @AndreiGoga_SF and @FKHM labs! Shout out to co-authors @Gentremet, @JulianeScience, @lisacfishsci among others! nature.com/articles/s41556-0…
2
29
89
37,105
4 May 2023
Very grateful to our collaborators at Genentech, Adam Palmer's lab, @ac_palmer, Matt Vander Heiden's lab, @mvh_lab, and Omer Yilmaz's lab @ohyilmaz, and of course the Koch Institute! @kochinstitute
1
8
1,969
4 May 2023
In the bioRxiv paper, we find that 5-FU shows no synergy at the cellular level with the DNA damaging drugs oxaliplatin or irinotecan - the combination given for GI cancer Rx. Instead, ribosome and tRNA biogenesis is impaired, driving an apoptotic signal that does not require p53
1
1
16
1,999
4 May 2023
RNA Damage? Happy to share Jung-Kuei Chen and Karl Merrick and @LabYaffe preprint that reports the major mechanism of 5-FU action in clinically relevant cancer treatment is through damage to structured RNAs...biorxiv.org/content/10.1101/….
1
14
49
7,506
Michael Yaffe retweeted
29 Apr 2023
Great work from the @davidkcortez lab!
doi.org/10.1126/science.add7…
1
19
42
5,976
Michael Yaffe retweeted
20 Apr 2023
If we didn’t have tenure scientists never would have risen up to discard our dysfunctional publishing system
20 Apr 2023
What is your elevator pitch for academic tenure? That will resonate with your non-academic, working person neighbors?
5
7
80
54,943
19 Apr 2023
Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3. frontiersin.org/articles/10.…
1
6
9
1,737
Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk
We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
4
45
119
46,239