Yeah I’m just going to stay out of it today.

Sand watch in TouchDesigner //- Yunsu

If Britney Spears had a regular job this would be it.

I hate the tortured “organized around gametes” definition of sex but it’s the last best chance we have.

“Blink” from Doctor Who (2005) is still one of the greatest standalone sci-fi episodes ever made. Barely any Doctor, no giant spectacle, just pure high-concept terror built around the simple idea of statues that move when you stop looking at them.

Terence Meets the Machine Elves: A visual replication of the DMT breakthrough experience generated through a bespoke generative media pipeline. built in collaboration with: @noonautics & @alieninsect 👁️

Dansçıların birbirleri ile değil ritimle senkron olmaları apayrı bir seviye. Görsellik şahane.

The company behind this pill has raised $250 million and is running the largest clinical trial in veterinary history, and the science explains why investors are losing their minds. The drug is LOY-002, made by a company called Loyal. It works as a caloric restriction mimetic. It tricks the dog's metabolism into behaving like it's on a restricted diet without actually reducing food intake. The biological cascade this triggers is the same one that's extended lifespan in every species ever tested, from yeast to primates. The FDA has already accepted the safety data and the effectiveness data. Two of three regulatory gates cleared. The third is manufacturing review, expected to complete this year. If approved, LOY-002 becomes the first FDA-approved drug for lifespan extension in any species. Not disease treatment. Not symptom management. Lifespan extension as a formal indication. The STAY study has 1,300 dogs enrolled across 70 vet clinics. Half get the pill, half get placebo. Both beef-flavored so nobody can tell the difference. It is the largest clinical trial ever conducted in veterinary medicine. Here's where it gets interesting for humans. Dogs develop the same age-related diseases we do: cancer, heart disease, kidney failure, cognitive decline resembling dementia. They live in our houses, eat similar food, breathe the same air. A mouse in a sterile lab tells you almost nothing about human aging. A golden retriever sleeping on your couch tells you a lot. Loyal has a second drug, LOY-001, targeting large breeds specifically. Big dogs die younger because centuries of breeding for size accidentally gave them elevated IGF-1 levels, which is the same growth hormone pathway linked to accelerated aging in humans. Reducing IGF-1 in flies, worms, and rodents extends lifespan. Loyal is now testing whether the same holds in dogs. 90 million pet dogs in 60 million US households. Average spending: $1,852 per pet per year. A pill that gives you two more years with your dog is the easiest sell in pharmaceutical history. Human longevity trials would cost $1 billion and take decades. Dog trials cost a fraction and produce data in years. Every dog in the STAY study is generating aging data that maps to human biology. The shortest path to an FDA-approved human longevity drug might run through your veterinarian's office.

2nd one! (It’s a Jeep thing) lol

Recent research from Kyoto University reveals that female dogs actively assess human competence—while male dogs do not. Female dogs clearly prefer approaching humans who successfully complete tasks, such as opening food containers, over those who fail. In contrast, male dogs show no preference and treat both competent and incompetent humans equally. These findings, published in a study titled "Female dogs evaluate levels of competence in humans," indicate that female dogs exhibit a more advanced form of social evaluation, particularly when food or resources are involved. They pay closer attention to human actions and their outcomes, using this information to decide who is the most reliable partner for obtaining rewards. This competence bias suggests female dogs are more sensitive to efficiency and social results than previously thought. For dog owners, it means your female companion isn't just loyal—she's also quietly evaluating your ability to provide. These results highlight an intriguing sex difference in canine social cognition, potentially evolved to enhance females' chances of securing resources and survival. [Chijiiwa, H., Horisaki, E., Hori, Y., Anderson, J. R., Fujita, K., & Kuroshima, H. (2022). Female dogs evaluate levels of competence in humans. Behavioural Processes, 203, 104778. DOI: 10.1016/j.beproc.2022.104778]

Unironically one of the best movie openings of the decade.

This is what professional bribery of a judge looks like

This is called Karen core and it’s the best thing I’ve seen in a while.

Try to keep up with that Y chromosome fellas

I was just told by my Wells Fargo branch that they can’t do withdrawals of over $1,000 until Friday. Ma’am….this is a bank 😐 It’s the end of the day. I could understand if they ran out of money for one day but to not have enough until Friday? This is the 21st century!

if a blind person accidentally bumps into you and you fall down, are they being 'violent'?

oh you’re off twitter for lent? Lent is about suffering, you should be here 24/7

um...am i missing something?

I think if we looked back at pre-transmania mass shooters we would find a lot of young men who fit the AGP/autist/oddball/too-online archetype, except trans wasn’t a thing yet. Meaning: being trans (taking hormones etc) is not causing mass shootings. But the people who commit mass shootings are the same people drawn to trans, now that it’s a thing that these maladaptors can identify into it.