GP South Park Commons, Pres Jimini, former CBO Immunai, CUEO Guardant, CEO iSkoot, EVP loopt, Pres DChoc, SVP iXL, founder/CEO Small World Sports/Software
Joined April 2007
- Tweets 1,461
- Following 1,272
- Followers 1,394
- Likes 1,898
63 Photos and videos
Pinned Tweet
30 Jan 2017
My great-great uncle Meyer Jacobstein en.m.wikipedia.org/wiki/Meye… was a 3-term Congressman from Rochester & opposed the Immigration Act of 1924
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Jun 13
So happy to have Ryan on the team!
Jun 12
We're thrilled to welcome Ryan to the
@southpkcommons team. He has been a force multiplier and a joy to work with!
blog.southparkcommons.com/p/…
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Jun 10
Imagine trying to type an email by blowing into a straw.
For 8 million people in the US & Canada with upper limb impairment, this is their reality.
@axionlabsinc has built a solution that restores dignity and independence with Click, a non-invasive BCI.
Watch my full chat with @Reddy_XX and @TinTunjic at @southpkcommons below.
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Jun 9
Working with @Reddy_XX and Tin as they build @axionlabsinc has been an honor. Their technology will bring dignity and hope to millions of people.
Jun 9
Ivan had a spinal cord injury three years ago that left him quadriplegic.
Last week, he ordered dinner from his favorite restaurant by himself.
This level of control used to need brain surgery. Not anymore.
Introducing Click by @axionlabsinc.
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Mark Jacobstein retweeted
May 15
My favorite thing about SPC is when our founders come full circle to support the next generation.
We welcomed @jonnydyer back yesterday to share lessons from building @MuonSpace and how they have grown the scope of their own ambition.
The future is bright!
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Mark Jacobstein retweeted
May 14
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Mark Jacobstein retweeted
May 11
Scott is amazing.
Very proud to have him as @southpkcommons alumni and to be an investor in Cognition (and LunchClub!)
May 11
Scott Wu is the co-founder of Cognition AI, one of the fastest-growing companies in history. He’s also the greatest competitive programmer the US has ever produced. You may have seen him doing impossible card tricks and mental math.
You’ve never seen him asked about weed, Michael Jordan, cancer, and human consciousness over a punnet of strawberries. That is what Colossus editor-in-chief Jeremy Stern did on a recent visit to San Francisco.
For those less familiar with @ScottWu46: In 2nd grade, he entered a math competition for 7th graders, lost, and was so furious he still fumes about it 20 years later. The next year he entered the 9th-grade division as a 3rd-grader and got a perfect score.
Then he won first place at the US national middle-school math competition and three straight gold medals at the International Olympiad in Informatics, where he became the greatest American gold-medalist and coach in history.
Most of the people running the biggest AI companies met as teenagers, competing for their countries on international math and science teams. OpenAI’s Greg Brockman, Anthropic’s Dario Amodei, Meta’s Alexandr Wang, to name just a few.
Most agree that the von Neumann among them was Scott Wu.
In November 2023, a few weeks after his mother died of lung cancer, on the day Sam Altman was fired from OpenAI, Wu founded his own AI company: Cognition.
He was 26 and saw earlier than almost anyone that AI would converge on agents that work in the background, 24/7, like coworkers. He shipped Cognition’s AI software engineer Devin in March 2024. It worked poorly, and he took intense public criticism for it.
Now, in its first 18 months of service, Devin has generated $445 million of revenue run rate and usage has doubled every eight weeks. The US Army, Goldman Sachs, and Mercedes-Benz are all customers. Cognition is raising at a valuation around $25 billion.
@JeremySternLA sat down with Wu, the emperor of the nerds, to ask the questions we’d all ask one of the smartest people in America—building the most consequential technology of our generation—if we ever got the chance.
As well as MJ and weed, they talk about the cluster of competitive math prodigies behind so much of AI, what makes us human when AGI arrives, and why Wu believes he was put on this earth to teach AI how to code.
Read the piece below.
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Apr 29
We have the 'bots. No, not those 'bots. Real f'ing Robots. Join us.
HACK ON ROBOTS AT SPC MAY 15-17!
Build something that moves. Three tracks: manipulation, aerial, & locomotion.
Mobile robots, drones, robotic arms, and 3D printers on site.
Apps due May 12th. Sign up now! 🤖
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Mark Jacobstein retweeted
Apr 29
Job postings for "forward-deployed engineer" have increased 10x in the last year.
We hosted @colintjarvis, @calvinleenyc, @jrshoch, and @howard_zuo at @southpkcommons to discuss what forward-deployed engineering really means and how FDEs are accelerating their deployment cycles.
Video soon!
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Today we're launching Scriben.
A pen. Real ink. Leather grip.
The second brain for knowledge workers.
It captures every voice conversation, transcribes, and turns it into memory.
For people who are paid to think — but spend their day trying not to forget.
Day one.
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Apr 21
I've been very lucky to work with @andrewpannu on Sleuth for the past few years. He's built an extraordinary platform; the most sincere praise I can give is to recommend that every biotech I work with use the product. It has become the go-to decision support tool for everyone who's tried it. Also, Andrew is rad.
Apr 21
We're launching Sleuth today.
The intelligence platform for biopharma's highest-stakes decisions, in use at top companies in the world.
To celebrate, we broke down the Chinese landscape: 18K assets & a map of the strategic white space. RT comment "Sleuth" for access.
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Mark Jacobstein retweeted
Apr 20
sleepwalking inside generative models, independent cancer research, visual hearing aids, and more...
our april demo night @southpkcommons was full of wacky and wild explorations at the frontier. check them out below.
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Apr 17
Really honored to have my friend @edwardjhu give a technical talk at @southpkcommons yesterday. Edward is wonderfully humble and real, and our members got to hear about his path from inventing LoRA and µtransfer, his PhD with @Yoshua_Bengio, to his current work as a researcher/entrepreneur running his own incubator.
If working on the frontier of AI and hardtech and learning from people like Edward is appealing, apply to South Park Commons
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Mark Jacobstein retweeted
Apr 1
More than 1 million people each week are having conversations about suicide with AI tools.
That level of demand points to a system under real strain and a clear need for infrastructure that can support it responsibly.
Jimini is building clinician-supervised AI for behavioral health, designed to work inside provider organizations. JImini helps care teams stay present between sessions, follow patient progress and extend support in ways that fit into clinical workflows.
Care decisions remain with licensed professionals.
We see this as an important step in scaling behavioral health services while preserving trust and quality of care.
As AI becomes more embedded in healthcare, the teams that earn trust will be the ones that build with clinicians at the center.
Proud to partner with Jimini Health.
Read more from @marissaplescia in @medcitynews: medcitynews.com/2026/03/jimi… @morgan_blumberg @mjacobstein
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Mark Jacobstein retweeted
March was packed at SPC...
a new model from @LumaLabsAI, a robot debut from @NobleMachines, new tools from @world_lica, @spc_india's 2nd-ever Demo Faire, events with @eladgil, @drfeifei, @stephen_wolfram, @Thom_Wolf, & more.
Read on⬇️
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Mar 30
The world needs (vastly) more intelligence; the world needs to use (far) less energy.
To solve this problem, @southpkcommons convened some of the world’s experts on the future of compute for an amazing half-day at Stanford. We heard about novel chemical processes for building the materials we need to advance semiconductors, and physics models for manufacturing these materials at scale. We learned about new chip architectures to exploit these materials, processes for designing and verifying these architectures, and algorithms (probabilistic, quantum, neuromorphic, and neuro-inspired) to exploit them.
None of these breakthroughs work on their own; new algorithms require new silicon (or something better!); the big unlocks occur when the innovation tunnels through the whole stack, and integrated gains can be non-linear. The advances will be entangled.
Similarly, everyone in the room benefited from the intermix of perspectives – chemistry, physics, EE, CS, neurobiology, and math, and teams from academia, startups, and industry. And perhaps the best part of the day was the fantastic constructive interference of all the sidebars.
This is exactly why I love South Park Commons – catalytic conversion is our reason for being, and density is the multiplier.
Huge thanks to Kerem Çamsarı, Tathagata Srimani, Christian Pehle, William Ludington, Ganesh Venkataramanan, Matthias Kling, Thomas Linker, SukHwan Lim, Subhasish Mitra, Andy Mannix, Volkan Gurses, Shridhar Mukund, and Gopal Raman for an amazing day.
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A couple weeks ago @adityaag and I gave a talk at @southpkcommons that sparked a bunch of discussion in our community.
The core tension: The opportunity to build has never been greater. So is the risk of building the wrong thing.
The founders who win won't just build faster, they'll move smarter. Pick problems the Eye can't see.
Full piece out today 👇
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Mar 23
Even after 8 months at @southpkcommons I'm amazed at the people who show up to talk...
Mar 23
You never know who a member will invite to stop by SPC... which is how @stephen_wolfram ended up holding an impromptu Q&A with the community last week.
We discussed everything from fundamental theory of physic to how the Wolfram products and community helped us through college!
S/o to @willsentance and @yaroslavvb for organizing!
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