Joined June 2015
- Tweets 30
- Following 14
- Followers 388
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11 Photos and videos
7 Jun 2024
Very proud to see Alvin's work end up as the cover story for this months issue of @LA_NatRes
nature.com/laban/volumes/53/…
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4 Jun 2024
Thrilled to announce that we have another paper out today in @SciReports showing how intracellular Salmonella Typhi infection alter the transcriptional landscape of human macrophages.
nature.com/articles/s41598-0…
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4 Jun 2024
Great to see this great work from Ruth Schade finally published and thanks to all funding sources and all of our collaborators @Salmonella
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3 Jun 2024
SalComFit:
We have published these thousands of fitness effects in a new #SalCom online resource bioinf.gen.tcd.ie/cgi-bin/sa…
The Gene Fitness Compendium developed in collaboration with Karsten Hokamp, Ada Luo @LijuanAda & Jay Hinton @Jay_Salsa.
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3 Jun 2024
We thank all our collaborators & co-authors for their contributions - and many others for reagents and feedback on our work!
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3 Jun 2024
Finally, we experimentally perturbed several serovar-specific gene networks & identify novel #pseudogenes in Typhi & Paratyphi A
The pseudogenes sensitize human-restricted Salmonella to stress - including metal homeostatic pathways
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3 Jun 2024
To systematically characterize these fitness events, we used @abarysh’s SAFE & other systems cofitness approaches to identify serovar-specific gene networks
We identified several gene clusters that ONLY have phenotypes in Typhi & Paratyphi A.
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3 Jun 2024
We extend this pipeline to investigate how different Salmonella serovars infect human THP-1 macrophages.
We identified genes ONLY required during infection by Typhi & Paratyphi A
= NOT required by Typhimurium.
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3 Jun 2024
We are thrilled to reveal our story in @NatureGenet on using high-throughput functional genomics to systematically study the biology of both generalist & human-restricted Salmonella: nature.com/articles/s41588-0…
This work was led by our postdoc @BenjaminXWang1
#Salmonella
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3 Jun 2024
We use Rb-Tn-seq to identify all genes used by Salmonella Typhimurium, Typhi & Paratyphi A to respond to 25 infection-related stresses encountered through human infection
= thousands of fitness effects !!
Rb-Tn-seq developed by Adam Deutschbauer & colleagues @Berkeleylab
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31 May 2024
Check out our latest paper on how temperature influences gut motility and stress in mice. Kudos to Alvin Han for all his hard work and thanks to all of our collaborators for making this paper happen! nature.com/articles/s41684-0…
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18 Sep 2023
We went for a lab-excursion to the CSHL microbial pathogenesis and host responses seeing a beautiful talk by Blanda on her Treg story, while Joy, Ruth and Daniel presented posters on their exciting stuff.
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29 Aug 2023
Congratulations to Alvin Han in the lab for successfully (and eloquently) defending his thesis work 👏👏👏.
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24 Jul 2023
Denise and Benjamin Wang are currently enjoying Italy at the GRC Salmonella conference. If you're around, make sure to go see Denise's beautiful poster and also to listen to Ben's exceptional story last thing Friday!! #Salmonella #Typhi #GRCSalmonella
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21 Jul 2023
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21 Jul 2023
Another successful thesis defence from Oscar Diaz and a soon to be ready manuscript that will hopefully pop up within a couple of months.
#Science #Stanford #Salmonella
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21 Jul 2023
Trung Pham and Denise published a seminal review on how intracellular bacteria rewire macrophages and creates a permissive niche for bacteria to thrive in.
sciencedirect.com/science/ar…
#Salmonella #Macrophages #Stanford #microbiology
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