'Bridging scales' from #smallmolecules to #cells. How can we combat the development of #humandiseases like #cancer? Max Planck Institute of Molecular Physiology
Joined March 2016
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May 27
NRAS mRNA-Degrading Bifunctional Small Molecules Induce Diverse Cellular Morphological Changes in #CancerCells
Published by the Peng Wu Group in @JACS_Au
pubs.acs.org/doi/10.1021/jac…
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May 19
The Gersch Group developed a well characterized matched chemical pair of inhibitor and degrader for the investigation of the #DUB #USP7 in #solidcancers together with the Cancer Center at the @UniklinikEssen Congrats to @NikolasKlink et al.!
nature.com/articles/s41467-0…
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Feb 19
Ancient co-option of LTR retrotransposons as yeast centromeres - New publication by the labs of Andrea Musacchio @maxplanckpress & Jef Boeke @nyuniversity published in @Nature - congrats to Max Haase et al.
nature.com/articles/s41586-0…
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Feb 4
Two new papers from the Musacchio lab published in The EMBO Journal!
link.springer.com/article/10… Kai Walstein, Louisa Hill & others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10… Arianna Esposito Verza and others – On mechanism of activation of PLK1
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Jan 29
We warmly welcome our new #LiseMeitner Group Leader Katerina Naydenova. Her group will investigate cellular defence mechanisms and develop novel methods in the field of cryogenic electron microscopy.
Learn more about Katerina and click on the link 🔗
mpi-dortmund.mpg.de/news/kat…
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Jan 23
We warmly welcome our new independent @maxplanckpress Group Leader Andrija Sente. His group will investigate the molecular mechanisms of neuronal communication.
Learn more about Andrija and his work and click on the link🔗
mpi-dortmund.mpg.de/news/new…
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Jan 8
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann, Slava Ziegler and Georg Winter @CeMM_News in @NatureChemistry
nature.com/articles/s41557-0…
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Jan 6
paper alert🚨
CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases - published by the groups of Tanja Bange @LMU_Muenchen & Andrea Musacchio in @NatureComms
nature.com/articles/s41467-0…
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1 Dec 2025
Paper Alert 🚨
Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders - published in @angew_chem by the Waldmann group
onlinelibrary.wiley.com/doi/…
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MPI Dortmund retweeted
9 Nov 2025
Pseudo-Natural Products Inspired by Aspidospermidine-, Strychnos-, and Koumine Monoterpene Indole Alkaloids Reveal Pyrimidine Biosynthesis Inhibitors (Herbert Waldmann and co-workers) • onlinelibrary.wiley.com/doi/…
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27 Nov 2025
Pseudo-Natural Products Inspired by Aspidospermidine-,Strychnos-, and Koumine Monoterpene Indole AlkaloidsReveal Pyrimidine Biosynthesis Inhibitors - published by Waldmann lab in @HelvChimActa dedicated to Armido Studer @uni_muenster
onlinelibrary.wiley.com/doi/…
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17 Oct 2025
Researchers led by Stefan Raunser have redefined the function & role of key factors in actin filament disassembly. "We uncovered a dance between proteins - a molecular choreography.” Congrats to @WoutOosterheert et al. @CellPressNews
➡️mpi-dortmund.mpg.de/news/dan…
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15 Oct 2025
"My time at the MPI Dortmund has been amazing! Not only have I made many friends, but I've also gained the required skills that laid the foundation for the next step in my career. " Congrats to @WoutOosterheert
on his new group leader position at the the @NKI_nl 👏
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14 Oct 2025
Using 16 (!) cryo-EM structures, the @Intein laboratory uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments. Congrats to @WoutOosterheert et al.
sciencedirect.com/science/ar…
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7 Oct 2025
We are happy to announce that we will have two new scientific groups led by Andrija Sente and Katerina Naydenova soon! If you are interested to join their lab as a PhD Student apply at our IMPRS!
➡️imprs-lm.mpg.de/
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29 Sep 2025
paper alert🚨
Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing - Published by the Laboratory of Peng Wu in @NatureComms
nature.com/articles/s41467-0…
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24 Sep 2025
Congrats to our former group leader Charles Loh on winning the Advanced Science Young Innovator Award 2025.
"My time at the MPI was a truly defining moment in my career! The excellent institutional support and the unparalleled freedom was pivotal to our discoveries!“
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24 Sep 2025
paper alert 🚨🔬🧊
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - published by @Intein lab & Zychlinski lab @mpiib_berlin
nature.com/articles/s41586-0…
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16 Sep 2025
Max Planck researchers have solved the mystery surrounding the ‘crown’ of #celldivision . They showed how the corona, an important component of the #kinetochore is constructed and how this guarantees the error-free distribution of #chromosomes
mpi-dortmund.mpg.de/news/cro…
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MPI Dortmund retweeted
15 Sep 2025
We want you! Join the Department of Molecular and Cellular Biology @MoCel_Geneva at the University of Geneva @unige_en @UNIGEnews @sciences_UNIGE
and become our new colleague!
Assistant (tenure-track) Professor or Associate Professor! Please RT - thanks
jobs.unige.ch/www/wd_portal.…
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