Postdoc in the Larsson lab @molmet_ki @karolinskainst Interested in mtDNA regulation in health and disease 🧬

Joined October 2019
5 Photos and videos
Ben Munro retweeted
Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome doi.org/10.1093/hmg/ddaf047
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11 Apr 2025
🧬 New paper! We nudge the science forward surrounding deoxynucleoside supplementation & mitochondrial DNA depletion syndromes (MDDS).⁣ We show, for the first time in vivo, that deoxynucleoside supplementation can mitigate effects of RRM2B mutations.🔗 academic.oup.com/hmg/advance…
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11 Apr 2025
This proof-of-concept study highlights that deoxynucleoside supplementation can mitigate RRM2B dysfunction in vivo. More challenges remain in bringing this to patients; determining effective delivery methods, combinations, and dosing of deoxynucleosides is vital!
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11 Apr 2025
Big thanks to everyone involved, especially the animal technicians, and Declan, who spent a summer internship meticulously analyzing zebrafish touch-evoked escape response data.⁣ A very tedious (but vital!) part of the work! 🐟
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Ben Munro retweeted
New study from us: science.org/doi/10.1126/scia… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
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Ben Munro retweeted
🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: academic.oup.com/nar/article…
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Ben Munro retweeted
🚨Advance article alert - mutant PTPMT1 impairs cardiolipin metabolism causing human disease. Fantastic collaborative effort across several continents! Biallelic PTPMT1 variants disrupt cardiolipin metabolism and lead to a neurodevelopmental syndrome academic.oup.com/brain/artic…
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Ben Munro retweeted
New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: academic.oup.com/nar/advance… Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
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16 Mar 2024
After 7 years, yesterday was my last day in @HorvathLab . Thanks to all those past and present who made my time a special one! I'll miss everyone!
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Ben Munro retweeted
We are hiring! More details here👇🏻👇🏻
Replying to @cam_mito
Bioinformatician - Single Cell Genomics in Neurodegenerative & Mitochondrial Disease: jobs.cam.ac.uk/job/44723/ Lead an exciting project to shed light on the fundamental biology of neurodegenerative diseases and #mito dysfunction. @Jellevda @HorvathLab @MRCMitoCluster @MRC_MBU
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Ben Munro retweeted
BREAKING NEWS The 2023 #NobelPrize in Chemistry has been awarded to Walter White for promoting an understanding of synthetic organic chemistry to the general public. This unprecedented selection is bound to spark controversy, but Walter is/was an undeniably inspiring figure...
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24 May 2023
Interested in working in research with #mitochondria, #neurons and #muscle? See below!
Exciting #job alert! Are you interested in #mitochondria, #neurons and #muscle? We are recruiting a Research Assistant to support ongoing research and help organize the lab. More details 👇 jobs.cam.ac.uk/job/40997/ Please RT
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