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Narayanan Lab @narayananlab

@narayananlab.bsky.social

Joined April 2010
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  • Followers 1,166
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Narayanan Lab@narayananlab
16 May 2024
#cppc2024!
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linkedin.com/posts/kumar-nar…

PNAS: Prefrontal Projections to Striatum and Thalamus | Kumar Narayanan posted on the topic |...

Excited that our newest work is up at PNAS: https://lnkd.in/gCbyz5cU Prefrontal projections are diverse - but maybe this complexity is defined by connectivity. We find that prefrontal activity is...

linkedin.com
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Congrats @BrookeYeagerMS on defending her PhD thesis!
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pubmed.ncbi.nlm.nih.gov/4196… Congrats to the @aldridge_lab on getting this important methods paper out!

Renovating the Barnes maze for mouse models of dementia with STARR FIELD: A 4-day protocol for...

Land-based spatial mazes are a low-stress method to evaluate learning in rodent models of dementia. By using innate exploratory and hiding behavior, the Barnes maze requires fewer trials, allowing...

pubmed.ncbi.nlm.nih.gov
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congrats to Hannah Stutt on defending her PhD on dorsal striatal dopamine and timing. Next step: on to awesome postdoctoral work!
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Excited for this webinar on Computational Properties of the Prefrontal Cortex from the Journal of Neuroscience: neuronline.sfn.org/scientifi… @SfNtweets

Computational Properties of the Prefrontal Cortex

“Ultimately, the investigation of prefrontal cortex function is fundamentally an effort to understand prefrontal computations” (Narayanan, et al. 2025).

neuronline.sfn.org
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Our latest paper showing that a few minutes of EEG can predict mortality in PD is now up: sciencedirect.com/science/ar…
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Our lab's posters at SFN @SfNtweets Saturday PM and Tuesday - see you there!
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Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!
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Our issue on Computational Properties of the Prefrontal Cortex is now: jneurosci.org/content/45/37?… These articles capture some of the incandescence of the CPPC conferences... narayanan.lab.uiowa.edu/home… cppc.web.ox.ac.uk/ accl.psy.vanderbilt.edu/blog… Next one in Toronto in ~2026!

The Journal of Neuroscience: 45 (37)

jneurosci.org
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D1FLP mice are now available from JAX! jax.org/strain/039507 Detailed in this paper: pubmed.ncbi.nlm.nih.gov/3970… Let us know if they work for you...
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Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : medrxiv.org/content/10.1101/…

Linear predictive coding electroencephalography algorithms predict Parkinson’s disease mortality...

Background Parkinson’s disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives We used...

medrxiv.org
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Narayanan Lab retweeted
Oliver Flouty@oliverflouty
9 Jul 2025
Credits go to my world-class team. I am especially grateful to my mentors who inspired and supported/funded my academic curiosity. Our goal remains: to bridge the gap to human studies and better understand the link between neurophysiology and subjective experience ❤️
Can SARICA@CANSARICA2
9 Jul 2025
Excited to share our latest paper in @TheJournal_Pain, led by my dear friend @oliverflouty (@USouthFlorida)! jpain.org/article/S1526-5900… Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation—revealing region- and frequency-specific modulatory patterns. Congrats to the whole team! @VBharmauria17 @NourShaheen_MD
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Our latest work: biorxiv.org/content/10.1101/… We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.

Timing, movement, and reward contributions to prefrontal and striatal ramping activity

Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if...

biorxiv.org
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Write-up of our amphetamine paper: psypost.org/amphetamine-scra…

Amphetamine scrambles the brain's sense of time by degrading prefrontal neuron coordination

Researchers have found that amphetamine alters how the brain processes time, increasing variability in the activity of neurons that encode temporal information. The study provides insight into how...

psypost.org
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another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.1101/… Led by @BrookeYeagerMS!
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Our latest preprint: biorxiv.org/cgi/content/shor…
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Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.neuropharm… Work by Matthew Weber @MatthewWeberPhD As always, data and code at: narayanan.lab.uiowa.edu/data…
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Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
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And we know the temporal code in prefrontal cortex – it’s ramping activity. Surprisingly, ramps didn’t change in slope, but became more variable! Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
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New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans: biorxiv.org/content/10.1101/… Data and Code: bit.ly/GlycolysisANDAD narayanan.lab.uiowa.edu/home…

Glycolysis-enhancing α1-adrenergic antagonists are neuroprotective in Alzheimer’s disease

Terazosin (TZ) is an α1-adrenergic receptor antagonist that enhances glycolysis by activating the enzyme phosphoglycerate kinase 1 (PGK1). Epidemiological data suggest that TZ may be neuroprotective...

biorxiv.org
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