@nelander_lab profile picture
Nelander Lab @nelander_lab

A research group at Uppsala University working at the interface of biology and big data informatics to develop novel therapies for nervous system cancers.

Joined November 2019
  • Tweets 86
  • Following 140
  • Followers 155
16 Photos and videos
Interesting talks and great insights on the Brain Tumour Conference 2024! Thank you @CRUKresearch for a wonderful organization that highlighted the latest exciting research on brain tumors 🧠
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🚨 Pre-print alert! In this work, we uncover the connection between brain tumor invasion and cell-state and identity three regulator genes that show promising potential to block invasive growth. Big thanks to all team members and collaborators! biorxiv.org/content/10.1101/…

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

Glioblastoma (GBM), the most common primary brain cancer in adults, is characterized by rapid local invasion along diverse routes, such as infiltration of white matter tracts and penetration of...

biorxiv.org
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Having a great time in Vancouver attending #SNO2023! Lovely to spend time with colleagues and listen to great scientists in the field.
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Yesterday Ida defended her PhD thesis! A thorough and compelling discussion was held between her and her opponent Dr. Itay Tirosh from the Weizmann Institute of Science. Congratulations Dr. Larsson for a work well done ✨
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A new paper out today by Emil Rosén and colleagues - Approximate Bayesian Computation can detect cell motion from single, still-life images of cells. This simple strategy enhances drug testing experiments aimed at targeting tumor cell invasion.
Communications Biology@CommsBio
13 Apr 2023
The spatial positioning of cultured glioblastoma cells is used to estimate cell motility and drug effects from single end-point images in vitro: doi.org/10.1038/s42003-023-0… @nelander_lab
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Check out our latest preprint presenting the algorithm scRegClust! Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers biorxiv.org/content/10.1101/…

Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

Nervous system cancers contain a large spectrum of transcriptional cell states, reflecting processes active during normal development, injury response and growth. However, we lack a good understand...

biorxiv.org
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Great presentation from Ida at the 13th NBCNS meeting in Gothenberg! Ida talked about her useful algorithm, the Single Cell Target Translator, which can be a tool in finding candidate regulatory genes essential in brain cancer development.
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We are very excited to be awarded this project grant from @KAWstiftelsen together with co-applicants @MatsNilssonLab, Kaska Koltowska, Lene Uhrbom and Rebecka Jörnsten!
KAW@KAWstiftelsen
14 Oct 2022
23 #research projects receive SEK 700 million Human impact on wild animals, why women suffer more often from autoimmune diseases are examples of awarded project grants by Knut and Alice Wallenberg Foundation #KAW100 #science bit.ly/3CWEfuB
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Nelander Lab retweeted
IGP_UU@IgpUu
14 Oct 2022
Stor grattis till Sven Nelander, Kaska Koltowska och Lene Uhrbom som fått ett miljonbidrag från @KAWstiftelsen!
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Replying to @ErinMGibson @Stanford
Next we had @nelander_lab showcasing computational approaches for understanding glioblastoma invasion and patient-specific vulnerabilities #CRUKBrain22
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Our last session at #CRUKBrain22 explores different approaches to optimise anticancer treatment efficacy while reducing toxicities, especially among children. Stay tuned & hear from @StanfordMed's @ErinMGibson, @UU_University's @nelander_lab & @DrMistyJenkins (@WEHI_research).
Pictures of Erin Gibson, Misty Jenkins and Sven Nelander. Picture of brain cancer cell, CRUK logo

ALT Pictures of Erin Gibson, Misty Jenkins and Sven Nelander. Picture of brain cancer cell, CRUK logo
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Listening to Sven doing a great job presenting many of the on-going efforts in the lab at the @CRUKresearch brain tumor conference.
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Milena presenting on route-specific mechanisms of GBM invasion at the @CRUKresearch brain tumor conference. Great work Milena! ⭐️
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Next future leader will be Milena Doroszko from Uppsala Uni. I'm braced... this could get computational! #CRUKBrain22 (PP)
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We are happy to attend the @CRUKresearch Brain Tumor Conference in London this week 🧠 Come visit us at poster #4, #57 and #34 in the break.
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It's time for the @CR_UK #BrainTumour Conference! Over the next 3 days, we're welcoming over 300 scientists & clinicians from across the globe to discuss the latest in #BrainTumourResearch and how we can accelerate progress for patients. Join the conversation using #CRUKBrain22.
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Looking for new opportunities? We are seeking an outstanding candidate for a postdoc position in cancer systems biology. Join our lab (nelanderlab.org) to uncover the secrets of brain tumor growth and invasion. Apply here: uu.se/en/about-uu/join-us/de…
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New paper from our group is out in @JNeurooncol. Patient-specific #zebrafish models of #glioblastoma, monitored by #neuralnetworks in an automated process: academic.oup.com/neuro-oncol…

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

AbstractBackground. Patient-derived xenograft (PDX) models of glioblastoma (GBM) are a central tool for neuro-oncology research and drug development, enabl

academic.oup.com
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Nelander Lab retweeted
Ramy Elgendy@Ramyelgendy
16 Sep 2021
Perturb-Seq scRNA-Seq >> Time-dependent unbiased detection of cell states of GBM!! This is exactly is what the @nelander_lab did in a study led by my colleagues @IdaLarssonSwe & Erika Dalmo and my humble contribution to the single-cell work. embopress.org/doi/full/10.15…

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Molecular Systems Biology - Tumor cell heterogeneity is a crucial characteristic of malignant brain tumors and underpins phenomena such as therapy resistance and tumor recurrence. Advances in...

link.springer.com
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