🚨FULLY FUNDED PHD POSITION!🚨 If you are interested in addressing the question of "How did climate shape the movements, interactions, and evolution of hominin populations?" Come join my lab at the Human Origins Excellence Cluster in Tübingen🧬🧪. Details: uni-tuebingen.de/universitae…
🧬We are born with hundreds of de novo DNA mutations that were not present in genomes of our parents. But why do some people have more of them than others?
In a new preprint the authors analyzed 28,985 sibling pairs and identified more than 800,000 de novo mutations. The main factor is parental age especially paternal age with about 1.5 extra mutations per year of the father’s age and 0.4 per year of the mother’s age
The authors did not find convincing evidence that the total number of de novo mutations is associated with genetic ancestry or parental smoking
The most interesting part is rare variants in DNA repair and replication genes. Disruptive variants in REV1 were associated with about a 16% increase in the total mutation rate while variants in LIG1 were linked to a 24 to 26% increase in CpG to TpG mutations
A key feature of the study was the analysis of IBD-segments in siblings genomic regions that both children inherited from the same parental chromosomes. Differences within these regions can point to new mutations.
biorxiv.org/content/10.64898…#deNovo#mutations#reparation#inheritance#siblings
🚨FULLY FUNDED PHD POSITION!🚨 If you are interested in addressing the question of "How did climate shape the movements, interactions, and evolution of hominin populations?" Come join my lab at the Human Origins Excellence Cluster in Tübingen🧬🧪. Details: uni-tuebingen.de/universitae…
"The regions in the Denisovan genome attributed to super-archaic introgression, are likely to have originated from H. erectus. Late Middle Pleistocene H. erectus may have coexisted with Denisovans." nature.com/articles/s41586-0…
I'm hiring! 📢 Come work with me on how different social pressures shape the evolution of new communication systems in the lab! Deadline for application is May 18th! mpi.nl/career-education/vaca…
🚨FULLY FUNDED PHD POSITION!🚨 If you are interested in addressing the question of "How did climate shape the movements, interactions, and evolution of hominin populations?" Come join my lab at the Human Origins Excellence Cluster in Tübingen🧬🧪. Details: uni-tuebingen.de/universitae…
Malaria was fundamental in shaping the course of human evolution, @CamZoology researchers have found.
From 74,000 to 5,000 years ago, early humans in Africa did not live in high-risk malaria areas.
This shaped how populations met and mixed, leading to the population structure seen today.
Read more about this new study in collaboration with the Max Planck Institute of Geoanthropology @MPI_GEA 👉 bit.ly/4e2V2PI
ALT A serene natural landscape featuring a reflective water body with lily pads, surrounded by lush greenery and distant trees. The foreground shows a small grassy bank. Text overlay reads " New Cambridge research: Malaria shaped the distribution of early humans across Africa."
Fantastic new paper from Eleanor Scerri's group and colleagues, led by Margherita Colucci, "Malaria shaped human spatial organization for the past 74 thousand years": science.org/doi/10.1126/scia…
🎥 Samantha Brown (CENIEH) explains how ZooMS refines the identification of fragmented faunal remains at Cova Eirós, improving our understanding of Neanderthal and Homo sapiens diets
🎥 Samantha Brown (CENIEH) explica cómo ZooMS permite identificar restos faunísticos fragmentados en Cova Eirós y mejorar la reconstrucción de la dieta de neandertales y Homo sapiens
#ICTSNews
New paper alert. My new article just published in Quaternary Science Reviews, "Revolution, modernity, and the dispersal of Homo sapiens beyond Africa". sciencedirect.com/science/ar…