The Timeline you’re reading now would be shocking to the person you were 5 years ago. And 5 years from now, the Timeline you’re reading today will seem quaint.

Therapeutic plasma exchange (TPE) can reduce microplastics in the bloodstream, but its health benefits remain uncertain. While TPE shows promise in removing microplastics, further research is needed to understand its long-term effects and clinical outcomes. mdsc.pe/4gtzexI

The world’s first anti-aging gene therapy has been injected into a human for the first time. In June 2026, Boston-based Life Biosciences announced that the first patient received a dose of their experimental therapy ER-100 in a Phase 1 clinical trial. The treatment uses partial epigenetic reprogramming by delivering three Yamanaka factors (OCT4, SOX2, and KLF4) to restore aged or damaged cells to a more youthful state. It is currently being tested as an injection into the eye for age-related optic neuropathies, including open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy (NAION). This milestone marks the first time partial cellular reprogramming technology has been administered to a human. While the current trial focuses on safety and vision outcomes in the eye, it represents a major step toward broader anti-aging applications. [Life Biosciences. (2026). Life Biosciences Announces First Patient Dosed in Phase 1 Trial of ER-100 for Optic Neuropathies. Company Press Release, June 9, 2026]

A Columbia ER doc wrote in @nytimes that she typed her own lab results into ChatGPT and got better care than her own doctor gave her — availability, patience, and truly customized diet and exercise steps (not just a generic handout). Her doctor's response to the labs was "book another appointment to discuss." I have to say I've asked patients many times to do just that. But ChatGPT was available immediately, not in two weeks or a month. It asked about her day, analyzed the ingredients in her vitamin gummies, and came up with a customized plan right away. For free. When I talk about tech making healthcare better and smaller, this isn't the better part. It's the smaller part — while patients (even patients that are doctors) getting better care than healthcare can provide. buff.ly/8fWpMrL #DigitalHealth #AIinHealthcare #FutureOfMedicine #healthcareAI

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NEWS: For adults with prediabetes, lifestyle intervention lowered risk of developing multiple chronic conditions. Read the full story ➡️ bit.ly/4enHPzl

Could matcha reshape your gut microbiome in just 2 weeks? 🍵 A striking clinical trial revealed that just two weeks of daily matcha consumption significantly remodeled the gut microbiome. Drinking matcha shifted 30 unique bacterial genera. In contrast, the placebo group saw changes in only 3. The Perspective: We often think of tea as just "antioxidants," but matcha is also a high-potency prebiotic. Your gut microbes ferment its specific polyphenols into short-chain fatty acids (SCFAs). This creates a "biological seal" for your gut lining: 🛡️ Barrier Integrity: Directly combats "leaky gut" markers. 🔥 Cytokine Regulation: Systemically lowers low-grade inflammation. 🧠 Metabolic Signaling: Supports the GLP-1 pathway naturally. You aren’t just hydrating; you’re "fertilizing" your internal pharmacy. Team Matcha or Team Coffee today? #GutHealth #Longevity #Matcha Source: Liu YC, et al. Appl Microbiol Biotechnol. 2020.

AI-driven tools appear to be steadily gaining acceptance among physicians, according to a recent survey from The American Medical Association (AMA). More than 4 in 5 doctors surveyed (81%) use AI in their practices, more than double the rate in 2023, results from the lobbying group’s 2026 Physician Survey on Augmented Intelligence found. “I think much of that is likely ambient listening AI scribe tools…where, we’re having a tool that takes notes for the physician, so he or she doesn’t have to during the visit as well as generates after-visit summaries,” AMA CEO John Whyte, MD, MPH, told Medscape Medical News. More on the survey: mdsc.pe/4xBxt84

A painless ulcer with a hard base is characteristic of: A. Chancroid B. Herpes genitalis C. Primary syphilis D. Gonorrhea