Building a legacy worth inheriting. CEO of Layton Ventures. Former CIO of ICAN. Co-creator and Former Senior Producer of The HighWire with Del Bigtree.

Joined April 2013
106 Photos and videos
He also just made more than 4300 new millionaires.
Elon Musk just became the world's first trillionaire. The typical American household would have to work more than 11 MILLION years to make Elon Musk's level of wealth. We need a wealth tax.
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Is the one-person company for real? AI has made execution cheaper than ever. But that doesn’t mean you’re suddenly worth fifty people. The real edge now is judgment, trust, distribution, and the thing no model can manufacture: you. My latest for Comfortably Uncertain. comfortablyuncertain.substac…
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Ten years ago, I walked away from a steady job with a baby at home, no income waiting, and no real plan. On paper, it made no sense. Looking back, it remains the smartest money I never spent. My birthday reflection on risk, faith, family, and the best bet you’ll ever make: open.substack.com/pub/comfor…
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“The Bitget preSPCX 80% Drop: A Token Split, Not a Crash The Bitget "crash" was a cosmetic price adjustment tied to SpaceX's own corporate action. According to Bitget's official announcement, the exchange rebranded preSPAX to preSPCX and implemented a 1:5 token split to align with SpaceX's official stock split, with each preSPAX token converting into five preSPCX tokens and the price per token adjusted accordingly — leaving the total value of user holdings unchanged except for market fluctuations.” Then this: “The Hyperliquid event was the real disaster. According to Unchained, the SPACEX-USDH perpetual on Hyperliquid's Ventuals market crashed 45% after Notice.co's oraclemishandled SpaceX's 5-for-1 stock split, triggering liquidations across 405 users and 1,393 trades.” This says less about Space X, and more about the fragility of pre-IPO synthetics. kucoin.com/blog/spacex-pre-i…
If you're not watching SpaceX (already -29% from all time highs) crash on Hyperliquid before it even IPOs, I don't know what you're doing with your life.
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Do you want a data center next door? AI data centers are popping up across the country, promising jobs, tax revenue, and digital "progress," but also raising serious questions about water, energy bills, noise, emissions, and who actually pays the price. The good, the bad, and the ugly of the data center boom. Read here: comfortablyuncertain.substac…
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Bill Ackman just dropped crucial insights on AI and investing at Liquidity Conference 2026: "This is the greatest era in history to build a business... unlimited compute, unlimited capital, incredible talent. But the risk of getting disrupted has gone up dramatically." He warns that everyone's chasing the shiny new thing (chips, semis, energy) while high-quality compounders like Amazon, Meta, and Microsoft are being ignored, trading like "old-fashioned" relics in the AI era. Watch the full clip. Are the Big Tech "dinosaurs" the biggest bargains? #BillAckman #AI #Investing #LiquidityConference
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AI capital is flooding into markets at a scale that should make every serious investor pause. Google. SpaceX. Anthropic. Alphabet. OpenAI. Berkshire. Data centers. Chips. Is this a cataclysmic exit-liquidity avalanche, or the infrastructure phase of a new era? Read here: substack.com/@comfortablyunc…
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Patrick Layton retweeted
Under capitalism, socialists are free to build socialism. Under socialism, capitalists aren’t free to build anything. Nothing stops a group of socialists pooling their money, forming a company, and splitting every wage and every pound of profit perfectly equally.... Or to donate all profit to the government. It’s legal. It’s easy. Owning the means of production is as simple as setting up a company. Marx wrote his manifesto before the invention of limited liability companies. Back then “seize the factory” meant seizing it from the handful of families who could afford one. That argument expired the day anyone could start a company with limited liability, raise investment and hire who they want. Socialists are free to lead by example and demonstrate their system works. They can out-recruit, out-motivate, out-build and out innovate based on their ideas if they like. It would prove the philosophy works. Capitalism will happily host their experiment. The fact that nobody does this tells you a lot.
I will soon be introducing a bill to give the public a 50% ownership stake in the largest AI companies in America. This would guarantee that the trillions created by AI are used to improve the lives of all of us — and block oligarch decisions that harm the American people.
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Two NIH researchers were just charged with conspiracy to smuggle monkeypox into the United States and making false statements to federal agents. They allegedly told CBP their shipment contained only “diagnostic and testing equipment.” Instead, agents found 113 vials — 18 of which have already tested positive for monkeypox. This is straight from the @FBI via @FBIsetroit. Worth paying attention to.
Jun 2
NEWS ALERT from @FBIDetroit: Two researchers with the National Institutes of Health were charged with conspiracy to smuggle monkeypox into the United States and giving false statements to federal law enforcement. A federal complaint alleges that the researchers told Customs and Border Protection (CBP) their case contained diagnostic and testing equipment. However, a investigation by CBP and #FBI agents uncovered 113 vials, 18 of which have been verified to contain monkeypox as of today’s date. This investigation was conducted by the FBI Detroit Joint Terrorism Task Force, along with assistance from the @FBIBillings' Missoula Resident Agency, the U.S. Customs and Border Protection team at Detroit Metro Airport, and the U.S. Department of Health and Human Services – OIG. Read more: justice.gov/usao-edmi/pr/fed…
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A roller coaster stuck 100 feet in the air is a and terrifying scene. Why are we seeing so many videos of stranded riders, breakdowns, and even ride failures? Are thrill rides becoming more dangerous? I looked at the safety numbers. The answer is more complicated than I realized. comfortablyuncertain.substac…
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"AI needs to be disarmed." Pope Leo, drawing a direct line from nuclear disarmament to artificial intelligence — and arguing AI must serve the common good, not become an instrument of domination, exclusion, or death. More on this at my Substack, here: bit.ly/AIPromiseAndPeril
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AI can be a powerful servant. It must never become our savior. My initial thoughts on Pope Leo XIV’s warning about AI, the Catholic faith, human dignity, and the danger of outsourcing conscience to machines. Read here: bit.ly/AIPromiseAndPeril
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Patrick Layton retweeted
Today, I released a report showing that Biden health officials knew that safety signals for COVID-19 injection injuries were being hidden by their VAERS analytic algorithm. They were shown an updated algorithm that signaled serious adverse events, but they refused to use it. Their cover-up jeopardized the health of millions of Americans. Read my interim report and see the records here:
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Patrick Layton retweeted
BREAKING: A former senior advisor to Anthony Fauci has been INDICTED for his role in the COVID-19 coverup This guy might throw Anthony Fauci under the BUS 👀 David Morens and his co-conspirators FALSIFIED records in an effort to SUPPRESS the lab-leak theory, and used his personal Gmail account rather than his NIH email in order to avoid being FOIA'd Fauci might just be next!
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Patrick Layton retweeted
Politico seems concerned nearly half of U.S. adults think "it’s damaging to require people to receive them.” Here's a clue Politico: it is damaging because mandates violate inform consent.
Vaccine skepticism among Americans is widespread, a Politico Poll found. Nearly half of U.S. adults surveyed in our poll signaled they think the science on vaccines remains up for debate and that it’s damaging to require people to receive them. 🔗 politi.co/4cbCPOM
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Patrick Layton retweeted
🚨LIVE: EP 471 | RFK Jr. takes action on microplastics; Jefferey Jaxen on AI and the data center debate; Del on treating COVID vaccine injury with Dr. Tina Peers; and Dr. Jerod Ochsendorf previews the Freedom Summit. x.com/i/broadcasts/1YxNrZNvP…
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Patrick Layton retweeted
Who is more likely to spread the pertussis bacterium (aka, whooping cough)—those vaccinated or those unvaccinated? The reality (see FDA, industry, and pharma scientists sources below) is that it is the vaccinated. Why? Two reasons. First, those vaccinated are less likely to have symptoms if infected with the pertussis bacterium but the bacterium still multiplies in their nasopharynx and they then unknowingly spreading it to others (instead of showing symptoms and knowing to isolate). Not science fiction—the hard cold facts as detailed below. Second, and this makes the reality even worse, because after an unvaccinated person has been infected with pertussis (and is more likely to have symptoms and stay in bed) that person won’t get infected again for at least many years – but the vaccinated individual can become infected over, and over, and over again with the pertussis bacterium because of the defective immunity this vaccine generates. But don’t worry, legacy media, no doubt won’t let the facts stand in the way of their hyperbolic reporting. They will blindly, like religious adherents, seek to blame, persecute, and shame those who do not inject this product instead of facing the reality: those vaccinated are more likely to spread this pathogen. If you don’t agree with the foregoing, take it up with the FDA, industry scientists, infectious diseases societies, and the hard cold data and science: - As the FDA explained in 2024: “aP [acellular pertussis] containing vaccines induce helper T cells (TH2) memory and neutralizing antibody responses that effectively prevent symptomatic disease but fail to prevent colonization and carriage.” fda.gov/media/181937/downloa… - As those considered the world's leading pertussis vaccine experts, pharma consultants, and infectious disease societies explained in a consensus paper on pertussis vaccine in 2019: “Natural infection evokes both mucosal and systemic immune responses, while aPVs [acellular pertussis vaccines] induce only a systemic immune response. … Mucosal immunity is essential to prevent colonization and transmission of B. pertussis organisms. Consequently, preventive measures such as aPVs that do not induce a valid mucosal response can prevent disease but cannot avoid infection and transmission. … aPV pertussis vaccines do not prevent colonization. Consequently, they do not reduce the circulation of B. pertussis and do not exert any herd immunity effect.” pubmed.ncbi.nlm.nih.gov/3133… They also explained that: “Lack of mucosal immune responses after aPV administration favor infection, persistent colonization, and transmission of the pathogen.” - pubmed.ncbi.nlm.nih.gov/2918… (“That vaccination does not prevent B. pertussis infection in humans, nor the circulation of the organism in human populations in any important manner, comes from the observation that the inter-epidemic intervals have not changed in a major way since the implementation of mass vaccination.”); pubmed.ncbi.nlm.nih.gov/3079… (“Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.”). For a detailed discussion with many more citations and irrefutable evidence, see Chapter 9 of Vaccines, Amen.

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My recommendations for FDA reform made at the Kennedy Center to members of the FDA and the public.
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