Functional Genomics working group of the Psychiatric Genetics Consortium.

Joined February 2024
8 Photos and videos
Pinned Tweet
20 May 2024
The PGC Functional Genomics workgroup serves as a dynamic hub for collaborative, open discovery science and scalable method development. We aim to understand how genes, cells and molecules impact the symptoms and course of psychiatric disorders in populations globally.
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🔑Key findings (3/3): ✨Differences in estimated cell composition and the identification of immune-related genes ✨suggests a potential role for immune system processes in OCD. 4/5 🧵
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🚨New paper alert!🚨 The bipolar disorder (BD) meta epigenome-wide association study (EWAS) by Tesfaye & colleagues is Out now in eBioMedicine 🔗bit.ly/4sGX9O6 🧵1/5

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🔑Key findings (2/2): 🔷Importantly, polymethylation scores (PMS) improved prediction beyond polygenic scores (PGS), 🔷especially for bipolar I disorder: combined PMS PGS models explained 18.5% of variance. 🧵4/5
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A big congrats to the team🥳, and don't forget to check out the full paper here 🔗bit.ly/4sGX9O6 🧵4/5

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3 Dec 2025
So, who are the the Functional Genomics Working Group? 🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠 We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪 🧵1/3
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3 Dec 2025
We have two awesome chairs ✨@HjerlingLeffler and @MLynall✨, who started the group in Fenruary 2024! We also have 5 project groups, 🔬exploring different ways of understanding #FunctionalGenomics in psychiatric disorders🧠 🧵2/3
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3 Dec 2025
Ultimately, we: 🌟drive inclusive and diverse 'omics' mental health research, 🌟and foster a collective effort that transcends individual capabilities for global science🌎! 🧵3/3
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PGC-FG retweeted
Before we get started, let’s introduce our two Social Media Reps - @BertholdNatasha and @Eva_C_Schulte! We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part! 💫Check out their profiles💫
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PGC-FG retweeted
✨Welcome to the Functional Genomics Takeover of the PGC main account!✨ For the next 2 weeks @BertholdNatasha and @Eva_C_Schulte will be taking you through the achievements and highlights of year 2 in the @pgc_fg.
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1 Nov 2025
Key Takeaways🔑: ✨EpiAnceR improves ancestry adjustment when genotyping data aren’t available ✨and is compatible with all major Illumina methylation arrays 🧵5/6
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1 Nov 2025
Such a huge congratulations to the team🥳 Remember, you can find the full article here 🔗bit.ly/49syndi #epigenetics #DNAmethylation 🧵6/6

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1 Nov 2025
✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by Kira Höffler & colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗bit.ly/49syndi Read our overview below! 🧵1/6

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1 Nov 2025
Results📊: ✨EpiAnceR improved on existing methods✨ Its ancestry PCs: 1⃣clustered repeated samples more tightly, 2⃣correlated more strongly with true genetic ancestry, 3⃣and outperformed methylation-based PCs and surrogate variables for ancestry correction 🧵4/6
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1 Nov 2025
Methods🗒️: To address this, the team developed EpiAnceR 🧑🏾‍💻, an R-based tool for ancestry adjustment in DNA methylation studies🧬 Function: 1⃣removes technical and biological noise, integrates SNP-related data 2⃣and generates ancestry PCs for downstream analysis 🧵3/6
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1 Nov 2025
Background❓: 🧬Genetic ancestry can confound DNA methylation results 🧬When genotyping data aren’t available, existing ancestry-adjustment methods often: 1⃣perform suboptimally, 2⃣or aren’t compatible with newer methylation arrays 🧵2/6
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