Joined August 2021
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15 Photos and videos
For the record, it is really important to mention two really deep review articles published earlier this year about the application of proline analogues in medicinal chemistry. First one written by the living legends, Hanessian and Meanwell:
pubs.acs.org/doi/abs/10.1021…
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And then the second one by a mixed group from China, who summarize a large massive of information on proline and its derivatives published between 2020-2025 in the medicinal chemistry context:
doi.org/10.1016/j.ejmech.202…
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There is a pretty cool recent publication that introduces bridgehead substituted [2]ladderanes as ortho-aromatic bioisosteres. Practical synthesis, structural analysis, and bioactivity validation.
pubs.acs.org/doi/abs/10.1021…
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Proline-rich antimicrobial peptides are still out there combating some nasty pathogens:
doi.org/10.1021/acsinfecdis.…
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Selective targeting of the key enzyme in proline biosynthesis:
doi.org/10.1021/acschembio.6…
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Well, this is interesting set of data. The effect of azetidine-2-carboxylic acid exposure on neuroblastoma cells.
doi.org/10.1016/j.fct.2026.1…
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Did you know that in chemistry you can ride bicycles? Very small. Really tiny. Yet, they can take you places you've never thought before.
Discover what these bicycles can do to bring us close to novel drugs in our recent review with @MykhailiukChem
pubs.acs.org/doi/10.1021/acs…
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What a sad message 😟 this used to be such a useful resource. Thank you, molinspiration team!
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15 Dec 2025
Production of xenoproteins on a gram scale. The incorporated noncanonicals include fluoroprolines.
Looks pretty cool to me! 👍🏾
doi.org/10.1002/cbic.2025006…
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18 Oct 2025
Very much enjoyed reading the newest review from Ned, Hamid and Huy on genetic code engineering. A summary of efforts, pitfalls and challenges.
doi.org/10.1002/cctc.2025008…
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11 Oct 2025
Really impressive review article on how to improve substance's solubility AND permeability at the same time, the trait combination that the authors called Aufheben. Great summary of strategies and examples from contemporary drug design! Open access
doi.org/10.1021/acs.jmedchem…
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10 Oct 2025
Just learned that chronic Staph. aureus readjusts its metabolism to feed on proline from collagen deposits. Mindblowing!
doi.org/10.1038/s41564-024-0…
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6 May 2025
A whole panel of 5-spirocyclic proline analogues prepared by colleagues from Enamine
doi.org/10.1039/D4OB01669F
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6 May 2025
Another amazing work from the group of JC Horng, unveiling the effects of cation-pi interactions in the assembly of the collagen triplex
doi.org/10.1021/acs.jpcb.4c0…
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6 Apr 2025
A fold stabilizing effect of a proline analogue on a 36 residues miniprotein
doi.org/10.1038/s42004-025-0…
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6 Apr 2025
Few interesting heteroatomic proline analogues in collagen mimetics. Seems that 5-oxaproline is well tolerated and accelerates the triple helical assembly. Great work!
doi.org/10.1039/D5OB00176E
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6 Apr 2025
Aromatic caps at the termini promote stability to triple helix in collagen mimics with just 4-6 GPO repeats
doi.org/10.1021/acs.biomac.4…
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6 Apr 2025
The importance role of central proline to the antimicrobial potency and selectivity of indolicidin
doi.org/10.1007/s00203-025-0…
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7 Jan 2025
I'm not a computational chemists, but would like to thank Prof Karplus for his work on rotation around peptidyl-prolyl amide bond, where they identified the major rotation pathway, and introduced the rotation transition state nomenclature. Merci!
1 Jan 2025
It is very sad to learn that Martin Karplus passed away on Dec 28 at age 94. He was a scholar and pioneering chemical physicist with great contributions in many areas including molecular dynamics. We interacted many times starting from my graduate time at Harvard. His legacy is reinforced by the large number of coworkers who have also done much to advance computational science.
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7 Jan 2025
I got a couple of new postcards from Genova and Berlin. Thank you for the Christmas cheer, Lars!
Happy 2025, everyone! I hope for a better year for all of you. Let your efforts pay off this year, my dear friends!
🍾🥂🎄🥳
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