What are the possible mechanisms linking short and long sleep durations with cardiometabolic outcomes? Is it possible for very short sleep duration to result in a proteomic fingerprint that is selectively associated with one cardiometabolic disease but not another? Our study identified 16 unique proteomic markers that were associated with sleep durations. When compared to a sleep duration of 7.21-7.57 hours, short sleep duration (4.00-6.57 hours), was linked with upregulation of markers of inflammation, apoptosis, and cell adhesion, and with downregulation of markers related to angiogenesis and resolution of inflammation. When combining these markers into a proteomic score based on their individual weights, we found that this score was significantly and positively associated with incident diabetes mellitus (DM) but not with incident coronary heart disease (CHD). However, individuals who developed diabetes during the course of the study were still at a significantly higher risk of CHD. The findings suggest that very short sleep duration has a proteomic fingerprint that is specifically associated with incident DM. It may also suggest the following pathway as one of the links between short sleep and incident CHD: Short sleep duration --> inflammation and apoptosis --> incident DM --> incident CHD Although long sleep duration has been linked with several adverse health outcomes including incident DM, our study did not identify an independent association between the markers predictive of the longest sleep duration and incident DM or incident CHD, thereby suggesting alternative pathways and mechanisms for such associations. doi.org/10.1186/s12916-024-0… #sleep #proteomics #Diabetes #inflammation

Pleased to share our latest publication in Sleep Medicine - a validation study of the Oura Ring that included 96 participants and over 420,000 epochs! sciencedirect.com/science/ar… #Sleep #Oura #Wearable #WearableTech #DigitalHealth

Okinawa, Japan, known for its high number of centenarians, healthy diet and lifestyle will be the perfect location for inspiring speakers and delegates to interact, update and progress the research to interact, update and progress the research field. 18th key Symposium / Hybrid

For improved quality of sleep, raise head of your bed by about 3” or 5cm and don’t eat 3 hours before bedtime

The latest research output from our group: onlinelibrary.wiley.com/doi/… #sleep #sleepresearch #occupationalhealth

Excellent commentary on sleep health and longevity! jamanetwork.com/journals/jam… #sleep #sleephealth #longevity

Our most recent publication in @JAMANetworkOpen suggests that sleep duration recommendations for adults in Japan, China, Singapore and Korea may need to be considered in the context of sex and age jamanetwork.com/journals/jam… #sleep #sleepresearch

This cohort study in Asia finds that when compared to 7 hours, all other sleep durations are associated with increased mortality risks in East Asian adults. Sex and age (in East Asian men only) are significant effect modifiers. @precision_sleep ja.ma/3n08Bop

Our article suggests that plasma Caspase 8 modifies the effect of sleep duration on incident diabetes and predicts incident diabetes years before disease onset. academic.oup.com/jcem/articl… #sleep #sleepresearch #biomarkers

Our article from 2018 suggests that incident diabetes may be the explanatory mechanism for the association between short and long sleep duration and incident CHD. link.springer.com/article/10…

Our research shows that self-reported sleep duration > 8 hours is associated with increased mortality in Japanese men and women. Approx. 20 years of follow-up! #sleep #sleepresearch doi.org/10.2188/jea.JE201902…

Our research finds that EEG-derived total sleep time and sleep onset latency are associated with the change in emotional status analyzed using voice patterns #sleep #sleepresearch #innovation formative.jmir.org/2020/6/e1…

Our research shows that @Fitbit Versa is valid for measuring total sleep time and time in bed in naturalistic longitudinal epidemiologic studies. #sleep #sleepresearch sciencedirect.com/science/ar…