Associate Professor, Section for Medical Biotechnology, Technical University of Denmark. Studies ubiquitin signalling in inflammation, metabolism, and disease.
Joined December 2015
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More evidence that LUBAC has functions beyond immune signalling. Our recent study shows that LUBAC and OTULIN regulate metabolic signalling: specifically they govern AMPK signalling to control metabolic adaption, autophagy, and cell death during energetic stress. This suggests that the metabolic symptoms observed in patients with LUBAC deficiency and ORAS, including glycogen storage disease, lipodystrophy, and liver disease, may be caused directly my metabolic dysregulation rather than being secondary to the systemic inflammation.
nature.com/articles/s41418-0…
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Rune Busk Damgaard retweeted
Jun 12
Thanks, but your description contradicts my experience. In practice your system heavily interferes with meaningful editorial control over reviewer invitations, which goes to the core of peer-review integrity. This isn't a 'communication shortfall'—it's a systemic choice you made.
Jun 11
2/3 By design, the Associate Editor’s expertise and reviewer invitations always take precedence. The peer-review system is built to support the editor’s decisions, and you retain the ability to revoke, replace, or invite additional reviewers at any point in the process.
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Rune Busk Damgaard retweeted
Jun 7
Anybody can write a grant that *proposes* "significant and rigorous" science. Many fewer actually *do* significant and rigorous science. If the latter is not considered, then why bother establishing a good track record anyway?
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🧵 Pandya et al. just landed in Cell with a “14-protein signature that predicts lung cancer 5 years out.” Nature did a news piece. The press is losing its mind. I read the methods. Someone has to. 1/10
Jun 5
Now online! Plasma signals of lung tumor promotion for molecular cancer prevention dlvr.it/TStsdr
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AI will be the end of universities! MOOCs will be the end of universities! YouTube will be the end! Libraries! The printing press!
And each time life continues almost as before. Universities provide peer interaction, evaluation, coordination and commitment. That’s the value.
May 30
You know what other tools know better than most instructors? Coursera and YouTube courses from top faculty, *the internet*, books from the library. How many students used those tools instead of formal ed? Very very few. How many will use Claude independently to learn the material? Probably the same amount.
I know it doesn’t sound glamorous, but the primary role of faculty is to get students in the seats and create incentives to actually absorb the information. This is your job. AI can help as a tool, I’ve seen some great harnesses of AI for education, but it will not do this.
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Rune Busk Damgaard retweeted
I am trying to build a framework that can use all the these published atlases
Despite of so many cell atlases being published, the reusablility is really poor
Tons of animals and money just being flooded away without reaching a proper researcher 😢
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Rune Busk Damgaard retweeted
May 29
Can someone start a journal called “Cell Atlases” so that the rest of the journals can go back to publishing interesting things?
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Medmindre opgaven er at bruge AI, giver det ingen mening at bede gymnasieelever skrive hjemmeopgaver. Utroligt, det ikke er lavet om for flere år siden. Sæt dem til at skrive opgaver i hånden henne på gym uden adgang til AI og bedøm dét.
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May 28
Nå, de unge snyder i gymnasiet. Tænk en gang! Men AI fylder så meget, at lærerne ikke stoler på det, de læser. Hvorfor så overhovedet bruge tid på at lære fra sig? Og endnu vigtigere, hvad er det eleverne bruger tiden på, når de AI-generer deres opgaver. Artikel om det (m. link):
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Hej @omDSB. Hvorfor kan man ikke købe returbilletter ud jeres nye “købsflow”? Hvorfor skal jeg købe to individuelle billetter og betale af to omgange? Jeg kan heller ikke vælge sæde? Men blot at jeg gerne vil have et…?Det er en seriøs downgrade af jeres billetbutik og service.
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May 22
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact ThermoFisher has systematically manipulated antibody validation data. Short Thread... 🧵
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It seems quite the fad these days, even among scientists, to assert how well AI can perform "science". Or maybe that's just what X amplifies.
In any case these obligatory genuflections to AI just accept the definition of science as being mundane literature reading, run-of-the-mill associative hypothesis testing, and brute-force data gathering and model fitting.
They don't differentiate competent but iterative work from the truly out of the ordinary and creative. Both are important, but only one is emulated by AI.
May 20
Today we all lost our jobs.....
Three Nature papers showing that scientists in the conventional sense are obsolete
At least read the first one.... the AI replaced all things that the scientist does ....
nature.com/articles/s41586-0…
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Rune Busk Damgaard retweeted
May 20
I sure hope AI gets a high paying job because it's going to need $12,850 for each of the thousands of papers a month it's going to be publishing in Nature.
Also a concern is whether it will have enough left over every month to pay the mortgage for the data center where it lives.
May 20
Today we all lost our jobs.....
Three Nature papers showing that scientists in the conventional sense are obsolete
At least read the first one.... the AI replaced all things that the scientist does ....
nature.com/articles/s41586-0…
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Rune Busk Damgaard retweeted
May 17
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.
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Rune Busk Damgaard retweeted
May 16
Still think we’re understating the impact of AI on university degrees. A growing numbers of students don’t just lack the inclination to read but the *capacity*. Literally unable to read and absorb difficult sentences for an extended period. Same goes for writing.
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May 14
i'd watch a whole season of this
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Rune Busk Damgaard retweeted
May 12
UK universities are miraculous. A case in point is the University of Sheffield, which has a total endowment of £59m (about 21x Princeton's per-student endowment) and 6 Nobel prizes. We're losing one of the most cost-effective research juggernauts on Earth.
Sadly, Chemistry may well be for the chop @sheffielduni too soon. It's not like it's produced any important alumni or anything 🤔
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Rune Busk Damgaard retweeted
May 11
A modest proposal: If you submit a manuscript with a made-up citation—not a bungled or misspelled reference—you receive a 5-year ban on having your work reviewed at that journal.
May 10
Oy. According to a new paper in The Lancet, the rate of made-up citations in biomedical papers has increased by more than 12x since 2023. thelancet.com/journals/lance…
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Rune Busk Damgaard retweeted
One of my NIH grant reviews came back last year with comments clearly LLM-generated. The PMIDs cited against the proposal were hallucinated. The papers did not exist. The score still counted toward the funding decision.
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May 4
"Mens Alternativets forperson i København, Birgitte Kehler Holst, var på ferie i Chile i december og januar. ."
Og det var Chile. Svømmere hun mon derned, siden hun tillader sig at være så hellig på de ældres bekostning?
ekstrabladet.dk/nyheder/poli…
Se lige det her klip.
Her forsvarer Alternativet Københavns Kommunes madpolitik, hvor ældre plejehjemsbeboere maksimalt kan få serveret 80 gram oksekød om ugen.
De ældre på plejehjemmene har hele deres liv betalt den skat, der har finansieret velfærdsstaten.
Nu har de selv brug for den. Og så skal de finde sig i at blive dikteret, hvor meget oksekød de må spise om ugen, af kommunen. 80 gram.
Det er respektløst. Lad de ældre selv bestemme deres kost i samarbejde med den lokale køkkenchef.
Støt vores arbejde for de danske skatteydere! Bliv medlem af Skattebetalerne i dag:
skattebetalerne.dk/vaer-med/
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