Latest from the lab! Led by @XueningHe922, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for TF cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!
Excited to share DeepCompARE ISA - a lightweight deep learning model efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations!
Preprint: biorxiv.org/content/10.1101/…
Github: github.com/anderssonlab/Deep…
🚨Job alert! 🚨
We are hiring a computational postdoc or PhD student focusing on
- modeling gene regulation using single cell data
- investigating the mechanisms of regulatory genetic variants
PhD student: employment.ku.dk/all-vacanci…
Postdoc: employment.ku.dk/faculty/?sh…
Check out our latest work, scE2G, for mapping the target genes of enhancers from single cell data! biorxiv.org/content/10.1101/…. See 🧵 below for highlights
Amazing work led by co-first authors @mayayayas and @613weilin in a great collaboration with @jengreitz 's lab
Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks.
biorxiv.org/cgi/content/shor…
Read more below!
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Happy to share our joint work with the Falsig Pedersen group on how the physical microenvironment can drive cells to acquire cancer hallmarks. cell.com/cell-reports/fullte… . In solid tumors, niches with low pH are common. We show that pancreatic cancer and normal organoids...(1/N)
Sooooo excited to share the first paper from the lab now online @NatureGenet 😀😀😀
Interested in MYC, transcriptional mechanisms and (breast) cancer? Check it out👉rdcu.be/dAAht.
Short summary thread 👇
A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? rdcu.be/dzTba@ItaiYanai@JefBoeke
How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s41586-0…@BoXia7
An encyclopedia of enhancer-gene regulatory interactions in the human genome
x.com/argschwind/status/1724…
Very proud—4 years in the making, huge team effort.
This is a paper where the author list cannot convey everyone's incredible contributions.
My holiday highlights below:
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“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved!
nature.com/articles/s41586-0…
Come and join us!
We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024.
This could be an ideal position for someone looking for 2 years of research experience before starting graduate school.
Apply: careers.peopleclick.com/care…
Congratulations to all our students who have done an excellent work as part of our @HorizonEU network over the last 3 years. Our @EMBO workshop starting today is a great opportunity to add a new dimension to their scientific careers.
#EMBOenhanceropathies
@MSCActions
Two training sessions on communication, led by @AlberichJorda , kick off our final event this afternoon.
See our program
EVENT VI ▶️bit.ly/3rPZQ59
Learn more about @enhpathy_H2020 ▶️ enhpathy.eu
@MSCActions
This will be my (academic) home during the fall. On a sabbatical at the Broad, kindly hosted by @kasper_lage and the @novonordiskfond center for genomic mechanisms of disease. Looking forward to lots of interactions and awesome science! Reach out if you want to meet up!
📢 PREPRINT ALERT 📢 Clustering cells is a key step in most scRNA-seq analysis workflows. It's hard, and harder with batch effects.
Our take on the problem, JOINTLY, use a hybrid linear and non-linear NMF. The non-linearity gives performance, the linearity gives interpretability
We are excited to share our study on the 5'FAD capping of #HCV RNA, which is out today in @Nature. The work is a close collaboration between my lab and the labs of Jens Bukh (not on twitter) and Troels Scheel @ScheelLab. Online at rdcu.be/df8p5 Major points here🧵1/15