Neuroskeletal Biology Laboratory (NSBL) @WUSTLmed. Executive director @wustlcrm. President @ISBM_society. Nerves. Bones. Metabolism. Encouragement. 🔬🦴🧠❤️
Joined July 2019
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Jan 9
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴
Full article here: lnkd.in/gH7eHv4r
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis dlvr.it/TQF2Gk
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Mar 18
A new study reveals how the brain triggers the breakdown of stable fat cells that normally resist diet and exercise. This discovery provides evidence for how severe wasting diseases cause dangerous weight loss in vulnerable patients. dlvr.it/TRYzzT
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A team led by @schellerlab @WashUDeptMed, with @XiaoZhang1994 and others identified a potent pathway that begins in the brain and leads to loss of all body fat without reducing food intake. Findings published in @NatMetabolism.
#WashUNeuroCommunity
bit.ly/4tL1AIg
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Feb 18
Specific brain signals rapidly eliminate body fat in mice source.washu.edu/2026/02/spe…
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Feb 12
Specific Brain Signals Rapidly Eliminate Body Fat in Mice
Sustained injection of leptin into the brain was shown to unlock stable adipocytes, leading to complete loss of body fat.
Researchers at WashU Medicine have identified a potent pathway that begins in the brain and leads to loss of all body fat without reducing food intake.
In mice, sustained injection of leptin, a hormone, into the brain was able to unlock the stable adipocytes by putting the body into a state of low glucose and insulin. This reduced the inhibitors of fat breakdown, causing complete loss of body fat within days, even though the mice were still eating normally.
Source in comments.
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Scheller Lab retweeted
Feb 11
RESEARCH | @schellerlab (WUSTL, US)
Stable #adipocytes resist lipolysis in healthy states but are highly susceptible to a #catecholamine-independent, #neurosystemic pathway-driven catabolic state🐭
nature.com/articles/s42255-0…
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Feb 11
#Activation of specific brain signals in mice triggers rapid, complete loss of body fat without reducing food intake, highlighting a potent neural pathway that regulates resistant fat stores. @wustl doi.org/hbn59g medicalxpress.com/news/2026-…
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Feb 13
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Jan 9
Many thanks to Dr. Affinati and Dr. Schwartz for their insightful commentary on our recent article in @NatMetabolism. 🙏 We are truly honored. Original manuscript link here: nature.com/articles/s42255-0…
Chewing the fat: a novel mechanism for lipolysis dlvr.it/TQF2QR
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13 Oct 2025
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27 Oct 2025
Exciting work by @AriellaStudies that we were proud to be a part of!
13 Oct 2025
Big anti aging news
Scientists Identify Core "Aging Genes" Shared Across Species. Silencing Them Extends Lifespan
Researchers publishing in Aging Cell have pinpointed a set of core genes that drive aging across multiple species, from humans to worms.
By analyzing 25 large gene expression datasets and testing the results in C. elegans, they found 6 key genes whose suppression extended lifespan by up to 15%.
These genes regulate immune activity, tissue maintenance, and DNA stability, and many are already linked to age related diseases like Alzheimer’s and macular degeneration.
The findings reveal universal aging mechanisms and new targets for anti aging therapies.
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15 Oct 2025
That's me! I'm Researchers! 😁
Very nice to see this excitement. 🎉
Original paper here: onlinelibrary.wiley.com/doi/…
13 Oct 2025
Big anti aging news
Scientists Identify Core "Aging Genes" Shared Across Species. Silencing Them Extends Lifespan
Researchers publishing in Aging Cell have pinpointed a set of core genes that drive aging across multiple species, from humans to worms.
By analyzing 25 large gene expression datasets and testing the results in C. elegans, they found 6 key genes whose suppression extended lifespan by up to 15%.
These genes regulate immune activity, tissue maintenance, and DNA stability, and many are already linked to age related diseases like Alzheimer’s and macular degeneration.
The findings reveal universal aging mechanisms and new targets for anti aging therapies.
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🎬And that's a wrap! Thanks to everyone that made #ISBM2024 a success. We hope you met some new buddies and left with new tools, ideas, and inspiration. We look forward to staying in touch until we see you again in London at ISBM 2026!
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3 Oct 2024
Live responses from the room on challenges in bone morphometry. Ok… who typed idiots? 😂😂😂 #ISBM2024
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3 Oct 2024
Followed up by a very neat live demo for setting up an AI-assisted image registration pipeline! Lots to learn for the biologists - but very cool to see an expert go through the steps in real time.
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3 Oct 2024
So difficult to pick just one! Great discussion and lots of questions at the #ISBM2024 training workshops. @ISBM_society
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This is not Hogwarts dinning room. That's #ISBM2024 Gala Dinner 😁😁 Sorry Mr. Potter
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Editor-in-chief of @JBMRPlus @dveislab shared with @ISBM_society members the vision of the journal in supporting the publication of protocols, mouse models, techniques articles that aim to advance the musculoskeletal research. Thanks Dr. Veis for this great initiative #ISBM2024
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