Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
Joined January 2016
- Tweets 25,146
- Following 249
- Followers 11,104
- Likes 9,899
13,581 Photos and videos
New review from @kalialabs & colleagues examines the translational gap between preclinical neuroprotection claims & clinical outcomes, focusing on how α-Syn-based models could resolve current limitations in deep brain stimulation research
journals.sagepub.com/doi/10.…
1
57
"PARK(ing) time" (catchy title)
How park deficiency affects the biological clock in a Drosophila model of #Parkinsons
febs.onlinelibrary.wiley.com…
41
Hillhurst Biopharmaceuticals announces that they have dosed the first participant in their Phase 2a clinical trial of HBI-002, a novel oral low-dose carbon monoxide therapy for #Parkinsons; Study seeks to assess the safety & tolerability
sg.finance.yahoo.com/news/hi…
1
210
Results of a randomized crossover pilot study of 5 patients with #Parkinsons demonstrates that gait-synchronized adaptive deep brain stimulation is feasible & safe, & reduces falls compared with continuous stimulation (NCT04675398)
nature.com/articles/s41591-0…
4
5
401
Researchers provide a modular decoding framework offering a blueprint for next-gen neuromodulation therapies that dynamically adapt stimulation parameters to the behavioral context, mobility demands & fluctuating physiology of each person with #Parkinsons
nature.com/articles/s41591-0…
1
2
289
Congratulations to Charlie Appleyard @CA_Annapurna - thoroughly well deserved honor!
lancasterguardian.co.uk/spor…
1
279
New paper finds "that data-driven subtyping, particularly the identification of the DM subtype, offers a promising strategy to optimize disease-modification trials in #Parkinsons by capturing patients who meet progression milestones earlier"
nature.com/articles/s41531-0…
3
1,192
Researchers conducted a retrospective case–control study (37,910 #Parkinsons cases vs 113K controls) evaluating associations between biomarkers, medication exposure, & PD; The previous associations of GLP-1R agonists, salbutamol & propranolol confirmed
nature.com/articles/s41598-0…
1
2
317
New research from @WadeMartinsLab & colleagues reports evidence of reduced neurosupport in both control & GBA-N370S iPSC-derived midbrain astrocytes exposed to inflammatory cytokines, suggesting a role for reactive astrocytes in #Parkinsons pathology
nature.com/articles/s41531-0…
1
3
475
New paper from @HirotakaIwaki et al presents a new #AI assisted approach that aligns data standards & accelerates interoperability in biomedical research, automating most tedious aspects of data integration & reducing barriers to cross-study collaboration
nature.com/articles/s41746-0…
367
Researchers present real-world clinical & economic data evaluation of remote programming for deep brain stimulation in #Parkinsons in China; Data suggests that remote programming could be a clinically equivalent, more equitable & economically advantageous
nature.com/articles/s44360-0…
1
1
278
The Science of Parkinson's retweeted
Jun 12
Interleukin-17 (IL-17 and its receptor, IL7R) is emerging as a key mediator in many immune-related diseases. Today @SciImmunology a superb review
science.org/doi/10.1126/scii…
4
107
392
43,026
New research proposes stimulator of interferon genes (STING) & the unfolded protein response (UPR) as key immune regulators targetable for therapeutic intervention during autoimmune diseases & #Parkinsons
cell.com/cell-reports/fullte…
4
9
914
New research explores the feasibility, reliability, & validity findings of a remote, self-administered, smartphone cognitive testing in a registry-based cohort (N = 1815; ages 18–92)
alz-journals.onlinelibrary.w…
1
252
There are lots of overlaps between #Alzheimers & #Parkinsons. A new mini-review explores convergent proteinopathies & mitochondrial dysfunction across the conditions
frontiersin.org/journals/neu…
1
3
354
Using multiple in vitro & in vivo models of #Parkinsons, researchers report that N-terminal acetylation slowed aggregation of both α-synuclein monomers & pre-formed fibrils; Could this post-translational modification represents a protective mechanism
sciencedirect.com/science/ar…
2
3
590
Is #Parkinsons simply "one phenotypic expression of brain aging rather than a discrete disease entity"? & could this reconceptualization "improve biomarker development, clinical trial design, and patient communication"?
prd-journal.com/article/S135…
1
297
AC Immune @AC_Immune_SA announces that they have received a research grant from Goradia Family to support extending Part 1 of the ongoing Phase 2 VacSYn trial of ACI-7104, an active anti-alpha-synuclein immunotherapy (vaccine), in early #Parkinsons
ir.acimmune.com/news-release…
1
3
302
Gene therapy company Belief Biomed & collaborators published the results of their Phase 1 pilot study of a dual-target gene therapy for #Parkinsons; 12-month primary safety/tolerability data for BBM-P002 (AAVT42 TH AADC) in 10 participants; Encouraging
nature.com/articles/s41591-0…
1
7
833
Interesting write up on safety monitoring in gene therapy trials, which mentions this trial & the challenges asociated with scaling up to larger Phase 2-3 multi-center trials
clinicaltrialvanguard.com/ar…
1
267
Interesting: @biogen researchers publish preclinical data (mice & NHPs) evaluating intracisterna magna & intraparenchymal administration of a AAV9-GBA1 gene therapy approach for #Parkinsons, which concludes "further technological advances are needed"
cell.com/molecular-therapy-f…
2
484