@scotomorph profile picture
Marija Krasiļņikova @scotomorph

Parasitologist | McCulloch Lab @ University of Glasgow

Joined December 2014
  • Tweets 226
  • Following 101
  • Followers 132
42 Photos and videos
Marija Krasiļņikova retweeted
Jeziel D. Damasceno@jezielbqi
6 Aug 2025
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. cell.com/cell-reports/fullte… Big thanks to Mike Boemo
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Marija Krasiļņikova retweeted
Carlos Robello@carlos_robello
1 Apr 2025
32 T2T!!! Happy to share our preprint showing the molecular karyotype of #Trypanosomacruzi @GonzaloGreif @fdiazviraque #MariaLChiribao @CarlosSanz22 @PacBio HiFi biorxiv.org/content/10.1101/…

Trypanosoma cruzi Has 32 Chromosomes: A Telomere-to-Telomere Assembly Defines Its Karyotype

Trypanosoma cruzi , the causative agent of Chagas disease, exhibits remarkable genomic plasticity and possesses an expanded genome rich in multigene families. However, its precise chromosomal...

biorxiv.org
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More recent work from the McCulloch lab! Check out Jeziel's @jezielbqi recent paper on R-loops, DNA replication and genomic stability in Leishmania major nature.com/articles/s41467-0… in @NatureComms @McCulloch_Group @MarquesCata @rmc9z @emmabriggs6

R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania

Nature Communications - All genomes are replicated in a temporal order, though the determinants of such timing are poorly characterized. Here, the authors show that the unusual chromosome...

nature.com
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Marija Krasiļņikova retweeted
Jeziel D. Damasceno@jezielbqi
8 Feb 2025
Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published! nature.com/articles/s41467-0… @McCulloch_Group @emmabriggs6 @scotomorph @MarquesCata
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
17 Jan 2025
We're pleased to share a new paper @UofGSii @WCIPGLASGOW led by @scotomorph @MarquesCata where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome. Well done Marija! doi.org/10.1038/s41467-025-5…
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DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s41467-025-5… thanks to @rmc9z @MarquesCata @emmabriggs6 Dario, Kathryn, Graham and Craig! 🥳

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and...

Nature Communications - A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and...

nature.com
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Marija Krasiļņikova retweeted
Trends in Parasitology@TrendsParasitol
17 Dec 2024
Drs Stephen Larcombe @jane_munday & @rmc9z highlight @MonicaMugnier & colleagues’ @Nature article on tissue spaces as #reservoirs of #AntigenicDiversity for #Trypanosoma #brucei. @SBSatEd @WCIPGLASGOW @UofGSii @JohnsHopkinsMMI @JohnsHopkinsSPH #Trypanosome cell.com/trends/parasitology…
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Marija Krasiļņikova retweeted
Joana Faria@JoanaRCF
10 Dec 2024
Are you interested in genome maintenance, organisation and replication? We have a BBSRC-funded PhD position to use multi ‘omics’ approaches to tackle this problem! ⁦@McCulloch_Group⁩ ⁦@UniOfYork⁩ ⁦@YBRI_UoY⁩ findaphd.com/phds/project/ma…

Making sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem… at...

PhD Project - Making sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem… at University of York, listed on FindAPhD.com

findaphd.com
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Marija Krasiļņikova retweeted
Jeziel D. Damasceno@jezielbqi
10 Dec 2024
Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At @McCulloch_Group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇
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How does Leishmania major replicate its genome? A sneaky Sneak Peek at a recent manuscript from our lab @McCulloch_Group (led by Jeziel @jezielbqi) currently under review: dx.doi.org/10.2139/ssrn.5045…
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
15 Nov 2024
Very happy to share new work @UofGSii @WCIPGLASGOW led by @jezielbqi describing very abundant, previously undetected DNA replication activity in Leshmania using DNAscent, a technique developed by @CNieduszynski Great work, Jeziel. shorturl.at/G7uRm
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
28 Oct 2024
Funded PhD available with us, @martllewellyn and James Cotton @UofGSii @UofGSBOHVM @WCIPGLASGOW to study genome replication and (in)stability across diverse kinetoplastids. Applications (via FindaPhD) taken from Nov 1st - Jan 12th. Enquiries welcome. tinyurl.com/mfz4yh3k
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Is 915 jupyter notebook cells an indication that it's time to move on to analysing some other data?
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
8 May 2024
Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6 biorxiv.org/content/10.1101/…

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and...

The genome of Trypanosoma brucei is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface...

biorxiv.org
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
2 May 2024
We’re pleased to share a new study led by @jezielbqi describing how R-loops and RNase H1 dictate chromosome size-dependent DNA replication timing and genome stability in Leishmania @emmabriggs6 @scotomorph @MarquesCata biorxiv.org/content/10.1101/…

R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication...

Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania , a human protozoan parasite,...

biorxiv.org
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This trypanosome chromosome looks like it's having a great time, no?
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And this one's doing cartwheels
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Marija Krasiļņikova retweeted
McCulloch Lab Group@McCulloch_Group
30 Oct 2023
We're very happy to share this study in @NAR_Open, led by @mggrzl and @emmabriggs6, describing R-loop interactors in T. brucei, including new functions in immune evasion. Great work, Mark, and thanks to all authors @UofGSii @WCIPGLASGOW rb.gy/rnu7w

Immunoprecipitation of RNA–DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved...

Abstract. RNA–DNA hybrids are epigenetic features of genomes that provide a diverse and growing range of activities. Understanding of these functions has b

academic.oup.com
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PhD thesis finally submitted, woo! I can rest in peace now
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Marija Krasiļņikova retweeted
Oxford Nanopore
@nanopore
18 May 2023
🚀🚀🚀 #NanoporeConf
Ahmed Abd El Wahed@ahmedAEW
18 May 2023
Replying to @nanopore
@nanopore allowed identification of non-cultivable bacteria in space station @NASA #NanoporeConf
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