ex-VC writing about the psychology of meaning, acceleration and modern ambition

Joined December 2016
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I wrote an article that’s been going crazy on Substack, maybe X will like it too: open.substack.com/pub/thewak…
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I wrote some thoughts on career for the next generation. I’ve talked to so many young people who feel disillusioned, lost and confused re: the job market. I hope this framework helps a few: open.substack.com/pub/thewak…
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Almost 250,000 people have read my article on ‘how to prepare for the next decade’. It’s really weird out there, people have been finding it helpful, you might too. open.substack.com/pub/thewak…
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I know all the cool kids are talking about TravisCore, Claude, the Strait of Hormuz, the techno-industrial complex or the collapse of terminal value… But I’m holed up in a little homestay in the mountains of Dharamshala, India and all that feels like some weird, synthetic fever dream we all got sucked into. Instead I wrote some stuff on the cost of all this acceleration, how we’ve lost the societal enzymes that process change and what we can potentially do about it. Iduno maybe I’ll catch a few people on X in a moment of weakness.
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Scott Barker retweeted
I wrote an article that’s been going crazy on Substack, maybe X will like it too: open.substack.com/pub/thewak…
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12,077
Scott Barker retweeted
I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level. Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness. Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.
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I wrote an article that went viral on Substack: How to Prepare for the Next Decade. We’re about to enter what I call The Acceleration Decade. Change will be fast, personalized and relentless. Here are 10 ways you can prepare:
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10. Do not give into cynicism The world looks bleak in a lot of ways. We face many challenges, tech acceleration only being one of them. We cannot become overwhelmed. We cannot lose hope. We are not bystanders in this world. We create the future.
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The future can be incredible. I believe it starts on the individual level. If we can all see clearly, we can begin to tackle bigger problems and design better systems. I wrote about all this in depth along with 10 exercises. Full article is here: open.substack.com/pub/thewak…

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