Great start to 2021 for team @sehgalpathlab for having their B-MRD paper published today in @PHOJournal. Special thanks to Reviewer 2 for all his efforts in improving the article and taking it to the next level @DrGauravNarula

Every Drop Shares Hope. Every Donation Saves Lives. #sehgalpathlab #WorldBloodDonorDay #BloodDonation #EveryDropCounts #LifeSaver #GiftFromTheHeart

Not everything attractive is harmless. Unmask the truth behind tobacco and choose freedom over addiction. #sehgalpathlab #worldnotobaccoday #saynototobacco #quitsmoking #quittobacco @drkunalsehgal

Not everything attractive is harmless. Unmask the truth behind tobacco and choose freedom over addiction. #sehgalpathlab #worldnotobaccoday #saynototobacco #quitsmoking #quittobacco

Only 3 Days Left! ⏳ Don’t miss the special Neu Life Check – Women Basic Package at just ₹2500 Offer valid till 31st May 2026 only! Home collection all over Mumbai - 02235193900 Because she takes care of everyone, it's time someone takes care of her. #sehgalpathlab #mother

Diabetes doesn’t always begin loudly. Sometimes, your body whispers first. Constant fatigue. Unusual thirst. Slow healing. Frequent cravings. The signs may seem small-until they aren’t. Early testing can make all the difference. Get tested. Stay ahead. #sehgalpathlab

May this Eid bring peace, happiness, and prosperity to you and your family. Eid Mubarak! #sehgalpathlab #festivals #festivalsofindia #eidmubarak

Kickstart your career in cytogenetics with hands-on clinical training at Neuberg Sehgal Path Lab. Gain real lab exposure, advanced diagnostic skills, and a strong foundation in Hematology & Oncology. Limited seats - Apply now - cytogenetics.sehgal@neubergdiagnostics.com

The greatest mom? Every mom. We asked kids about their moms and realized one thing: different moms, same unconditional love. At Neuberg, we believe best way to honour that love is by protecting their health. Happy Mother’s Day to the heartbeat of every home! #sehgalpathlab

Many of us misunderstand KMT2A leukemia. FDA says “translocation”—biology says fusion. FISH ≠ partner. DNA panels miss it. Only KMT2Ar responds. Break-apart tells you that. RNA tells you what. Biology tells you if it matters.

TP53 in MDS is not binary. It’s a spectrum. And we’re oversimplifying it ! Large SCT dataset confirms: • TP53-mut = adverse • “Biallelic” = worst Important work. But the biology is more nuanced. Monoallelic TP53? Bad. But how bad? We all have long-term SCT survivors → 👉 suggests residual function / heterogeneity True biallelic (multi-hit)? • Functional TP53 loss • Genomic instability • Near chemo-resistant state 👉 Very difficult to rescue, even with SCT But here’s the issue: “Biallelic” often defined as VAF >50% 👉 Useful shortcut 👉 Not biology VAF >50% ≠ biallelic VAF reflects: • Tumor purity • Clonal dominance • Copy number A dominant monoallelic clone can look like “50%” More importantly: 👉 What if TP53 is a 10% subclone? Different biology: • Less genomic dominance • Less clonal fitness 👉 GVL may still control this So TP53-mut disease is not one entity: • Monoallelic dominant • True multi-hit • Small subclonal TP53 ➡️ Different biology ➡️ Different outcomes Retrospective studies like this are critical —but limited by simplified definitions TP53 is a spectrum VAF is not allelic state True biallelic = genomic collapse Subclonal TP53 → may be GVL-sensitive See figure 👇 Dr Fun G #MDS #AML #Hemetwitter

Thank you. MYC rearranged ≠ Burkitt WHO5 / ICC: • Burkitt → MYC-R classic biology • DH/TH → MYC BCL2/BCL6 • HGBL-NOS → MYC-R, no partner • DLBCL can still be MYC Clinical truth: MYC = high-grade behavior signal

Kickstart your career in cytogenetics with hands-on clinical training at Neuberg Sehgal Path Lab. Gain real lab exposure, advanced diagnostic skills, and a strong foundation in Hematology & Oncology. Limited seats - Apply now - cytogenetics.sehgal@neubergdiagnostics.com