The Sigel lab focuses on the principles of metal ion-assisted folding and the structure of functional RNAs. | This group account is managed by students |
Joined April 2021
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32 Photos and videos
5 Jun 2025
There's a joint spotlight collection on Bioinorganic Chemistry between Chemical Science and Dalton Transactions - and our paper on elucidating the structure of G4 quadruplexes (pubs.rsc.org/doi/D5SC01416F) has been selected! Check out the collection here: rsc.li/bioinorganic-spotligh…
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15 Apr 2025
Congratulations to Matteo Lisibach for winning the Semesterpreis of the University of Zurich for his outstanding master thesis entitled "Toward multiple coordinates: Resolving the intrinsic heterogeneity of a group II intron folding and splicing process". Very well done Matteo!
ALT A folded RNA molecule in the confocal volume of a microscope and a graph showing excitations in the Cy3 and Cy5 channel. Expanding the single-molecule FRET toolkit to tackle complex macromolecular dynamics.
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7 Apr 2025
Do you want to assign solution structures of G-quadruplexes using NMR? Maybe this new approach we just published works for you. Congrats to Zhenghui and Carla for this amazing work!
doi.org/10.1039/D5SC01416F
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Sigel Lab retweeted
14 Feb 2025
We are delighted to announce the Inorganic Chemistry Frontiers Outstanding Paper Awards 2014–2023！
Please join us in congratulating our winners, we hope you enjoy reading their outstanding articles as much as we did.
rsc.org/journals-books-datab…
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3 Sep 2024
Roland and our PostDoc @LindlarNiko visited the EuroBIC17 in Münster last week. While Roland presented our work on the recently discovered theta ribozymes, Niko spoke about one of his projects from his Ph.D. in the @DaumannL Lab.
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3 Sep 2024
A big shout out to @MuellerChem from Münster as well as Metzler-Nolte Lab from Bochum and Herris-Pawlis Lab from Aachen for putting together such a well-organized, well-caffeinated, and well-scienced conference!
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23 Aug 2024
The Sigel group is coming out of the summer with a few news:
Besim defended his Ph.D. thesis on illuminating the structure-function relationships in group II introns successfully! 🥳🥳Stay tuned for a publication about this!😉
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23 Aug 2024
We also would like to welcome Lennart Lindner in our group! Lennart started his Ph.D. thesis this month in the smFRET group - we wish successful experiments, good coffee and many new experiences!🙏
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12 Jun 2024
After 9 months it is time to say goodbye to our Japanese exchange student Minako - thank you for all the work you put in your NMR studies and, of course, the delicious cake!
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8 Jun 2024
The chemistry booth at Science and Nature Festival powered by the Sigel lab - come join us at Campus Irchel today!
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8 Jun 2024
We scientists have a responsibility to act against climate change. Part of that is advising and educating the public and part of it is keeping our own house in order. So, we applied and got the bronze LEAF - Laboratory Efficiency Assessment Framework - medal!
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17 May 2024
The Sigel group is starting into summer with two new members: We welcome Benjamin and Matteo for their Master projects! Benjamin is doing a specialized Master in our NMR subgroup while Matteo is doing smFRET studies. We wish few failed experiments and lots of fun in the lab!
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9 Feb 2024
We congratulate Federico Held for completing his master thesis with us. Federico introduced a heteroatom into RNA and used this to look at the BCL-2 RNA G-quadruplex. Thanks for the great time Fede!
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29 Jan 2024
Last friday the Sigel group traveled to Bern. Why? To learn about RNA research in Switzerland at the Swiss RNA Workshop. Besim Fazliji, a Ph.D. candidate in our group, gave a talk about " Dissecting the exon binding mechanism in group II intron splicing" - and it was great!
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Sigel Lab retweeted
14 Jun 2023
Check out our new preprint in collaboration with the @sigel_lab and find out more about Theta Ribozymes:
Thousands of novel HDV-like, self-cleaving ribozymes that are often found next to viral tRNAs.
biorxiv.org/content/10.1101/…
#tRNA #biochemistry #ribozymes #bioinformatics
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25 Jan 2024
Two weeks ago our Ph.D. students joined the CMSZH graduate school retreat - together with all other Ph.D. students from @UZH_Chemistry! It was a great time to enjoy Swiss mountains and learn about the fascinating research done at our own Department!
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25 Jan 2024
And, among other things,@KKienbeck presented the new hot topics in our research. Pictures by Fan Liu of the Holland Lab.
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6 Nov 2023
We congratulate Chantal Balmer on the successful completion of her Master's Thesis entitled "Influence of Substrate Structure on the Self-Cleavage of tRNA-Associated Ribozymes"! It was a blast having you!
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