Biodesigner.
Joined June 2009
- Tweets 592
- Following 115
- Followers 185
- Likes 226
16 Photos and videos
2 May 2024
Latest paper, Engineering is Evolution, is now out in @NatureComms! It was great fun working on this one with @chofski and @Michielstock doi.org/10.1038/s41467-024-4…
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Sim Castle retweeted
29 Apr 2024
#Engineering is #evolution 🧐 ...perhaps? In the latest from the lab @NatureComms we explore what "#design" might mean when engineering biology and the unifying role of evolution. Work led by the brilliant @simcastle with @Michielstock #synbio doi.org/10.1038/s41467-024-4…
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19 Apr 2024
Rhythmic Attractor, an album of biodelic music, is now on SoundCloud
on.soundcloud.com/rwJQs
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Sim Castle retweeted
31 Aug 2023
🚨In new work led by @simcastle, we consider what it means to engineer something and what exactly the design process is. By linking to key engineering literature that has been overlooked by much of #synbio to date, we find evolution is a unifying concept. osf.io/urq9w/
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Sim Castle retweeted
21 Jan 2022
📢Latest paper out @NatComms "Massively parallel characterisation of engineered transcript isoforms using direct RNA sequencing" We learn to control flows along DNA by repurposing terminators as transcriptional valves! @co_evolver @BrisBioDesign @synbioCDT nature.com/articles/s41467-0…
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Sim Castle retweeted
2 Jul 2021
"It took years — eight years and counting in exile — for me to realize that I was missing the point: we talk about conspiracy theories in order to avoid talking about conspiracy practices, which are often too daunting, too threatening, too total." edwardsnowden.substack.com/p…
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Sim Castle retweeted
27 Sep 2021
As always #IWBDA2021 was great! If you'd like to see what my lab is up to, my keynote is now available to watch online. I hope it sparks interest in some of you to go #beyondGFP and #engineerevolution! 🦠💻🛠️🦀 #synbio #biodesign #biocomputation youtube.com/watch?v=gyOI7FmX…
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10 Aug 2021
"carbon footprint" is a concept invented by BP to shift responsibility away from oil companies and onto individuals mashable.com/feature/carbon-…
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7 Jul 2021
Can anyone recommend a Bristol-based children's charity to give small cash donations?
Sim Castle retweeted
5 Jul 2021
New paper out in @NAR_Open on efficient use of dCas12a for multiplexed gene regulation in yeast 🥳 Epic effort lead by @KlaudiaCiurkot at @DSM as part of the EU SynCrop ETN. Great foundation for future genetic circuit design! #synbio #crispr @BrisBioDesign doi.org/10.1093/nar/gkab529
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15 Jun 2021
Turns out several creationist blogs have (wilfully?) misunderstood our paper. For the record: the thesis is that engineers can design *with* evolution, NOT that evolution came about through engineering. nature.com/articles/s41467-0…
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11 Jun 2021
I wrote a blog post about the paper I wrote with @chofski and @PR0FG #evotype #evolutionaryengineering
bioengineeringcommunity.natu…
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Great work, Joshua. Extra thanks for all the work you did on revisions for this during your EPSRC fellowship!
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Sim Castle retweeted
LSB scientists develop the ‘evotype’ to help unlock the power of evolution for better engineering biology.
Incredible work from @simcastle, @PR0FG, and @chofski!
Find out more at the link below:
bristol.ac.uk/news/2021/june…
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8 Jun 2021
One of the biggest inspirations for my art, music, and science is the beauty that exists between order and chaos. This is the region where life can evolve, where meaning emerges from information, and where consciousness is possible.
instagram.com/p/CP2cHi8pueR/…
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7 Jun 2021
My first paper is out today in Nature Comms "Towards an engineering theory of evolution"
7 Jun 2021
📢Our latest paper "Towards an engineering theory of evolution" where we consider the interwoven nature of #evolution & #synbio is out now in @NatureComms! 🎉 Lots to think about in this one. 🧐@simcastle @PR0FG @BrisBioDesign @BristolBioSci doi.org/10.1038/s41467-021-2…
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Sim Castle retweeted
15 Dec 2020
🥳 Refined and expanded... our updated “Engineering Theory of Evolution” This underpins a number of tough experimental projects in the lab as we explore how evolution can become become integrated into large-scale biosystem design! @simcastle @PR0FG #synbio preprints.org/manuscript/202…
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Sim Castle retweeted
24 Sep 2020
I'm sorry but this year it should be called "Lobby Universities, Funders and Governments To Actually Give a Damn About Postdocs Week" here's why... ⬇️
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Sim Castle retweeted
26 Aug 2020
📢An engineering theory of evolution! First preprint out from @simcastle introducing the concept of 'evotype' to enable us to reason about & design the evolutionary potential of engineered biological systems. @PR0FG @BrisBioDesign #synbio #evolution preprints.org/manuscript/202…
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