Patoshi Punks reverse-engineered Bitcoin block design is not limited to eye traits. The overall footprint for Patoshi Punks was also built from Bitcoin blocks. For example, the "Block" facial hair trait seen below was derived from Bitcoin block #59140, a 3-transaction Bitcoin block.
Quintessential Bitcoin-Native design.
Patoshi Punks were designed by looking directly into the Bitcoin mempool itself. Patoshi Punk eyes, for example, were reverse engineered by taking Bitcoin Block #41287 and placing it in a socket. In the Bitmap community (who originally identified these "Punk" shaped blocks), these 2-transaction blocks are known as Bitmap "Pristine Punks".
Just one of several reasons why Patoshi Punks are one of the most Bitcoin-Native PFPs in the Bitcoin ecosystem and considered collectors items.