Select your cell: I'm prototyping an interactive sc RNA-seq portal where the UMAP is dynamically linked to morphing 3D artistic renders of each cell type. You can play with the initial build below.
We often talk about pangenome reference but what does "reference" mean? If it means the whole graph, what is a variant? My collaborators Pouria and Luke give a clean answer: the reference is a spanning tree including GRCh38 and variants are leftover edges. See preprint for more.
New preprint on a surprising question - with a pangenome reference, *what is a genetic variant?*
biorxiv.org/content/10.1101/…
With Pouria Salehi Nowbandani, Shenghan Zhang, Haoyang Hu, and Heng Li @lh3lh3
The 19th International Conference on Data and Text Mining in Biomedical Informatics,
15-18 December 2025 (Muju, Republic of Korea)
I will be a speaker!
dtmbio.net/
Russia killed 31 people in Kyiv yesterday night. Among them were five children.
The youngest victim was just two years old.
159 people were injured, including 16 children.
🕯️
And the #CAMDA25 team continues with the celebration (including a visit to the super lambanana), wishing them all the best and looking forward to seeing you next year in the #ISMBECCB2025
Kinga Zielińska (Jagiellonian Univ.) opens the #CAMDA25, #ISMBECCB2025 the Gut Microbiota Challenge: Can we build a better microbiome health index? With 4,398 samples & taxonomic functional data, participants are encouraged to go beyond GMHI & hiPCA
David Danko (Biotia Inc.) presents BIOTIA-DX Resistance at #CAMDA25, #ISMBECCB2025, a clinically validated metagenomic workflow adapted for AMR prediction. With curated global data and stringent preprocessing, the tool reached an F1 score of 84 on the challenge test set
Owen Visser (Univ. of Florida) presents an ensemble ML model for AMR prediction at #CAMDA25, #ISMBECCB2025. Trained on strain-specific markers & AMR gene classes, achieving up to 98.2% accuracy (A. baumannii). Permutation analysis reveals key resistance genes in diverse pathogens
Jack Vaska (Stony Brook Univ) applies LLMs to #AMR prediction at #CAMDA25: Fine-tuned DNABERT2 models DBGWAS identify resistance-linked sequences across 9 pathogens & 4 antibiotics. Results show high accuracy, showcasing the power of deep sequence context in AMR genomics.
Now, Alper Yurtseven (Helmholtz Institute) tackles #AMR at #CAMDA25, #ISMBECCB2025 by predicting resistance across 9 key bacterial species using machine learning. With a focus on scalable, cross-species models in the fight against antimicrobial resistance.
🔬 Ever wonder how your immune system ages?
📊 We used single-cell multi-omics (RNA ATAC) bulk ATAC on PBMCs to build a cell-by-cell map of aging.
🧠 Find out which genes fade, which chromatin gates close and why some immune systems age slower.
👉 Poster C-482 #ISMBECCB2025
Honored to open day two of #BOSC2025 and BOKR joint session at #ISMBECCB2025 introducing @chrismungall opening keynote: Open Knowledge Bases in the Age of Generative AI