It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.

New paper with @theMaxwellLab : Phage reprogramming of Pseudomonas aeruginosa amino acid metabolism drives efficient phage replication doi.org/10.1128/mbio.02466-2…

Amazing work by @LandonGetz and team!

There are people that submit their grants more than 8 minutes ahead of the deadline???

🚨New preprint from our lab! We map the RNA interactions in E. coli infected by lambda, revealing an RNA-driven regulatory layer in phage-host dynamics. We find a phage-encoded sRNA hijacking host replication machinery, impacting the phage cycle.#microbiology #phages @MeetingRna

We’re here at @WCHospital for the #GairdnerScienceWeek Women of Gairdner Event! High school students, researchers and local faculty are here with 2024 Canada Gairdner Award laureates Drs. Meghan Azad, Gagandeep Kang, and 2022 #GairdnerAwards winner Dr. Deborah Cook Watch the webinar now! us02web.zoom.us/webinar/regi…

Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular development and antibiotic production in Streptomyces. Postdoc: shorturl.at/f8NTN PhD position: shorturl.at/qCFmN Email me for more information.

This was a wonderful meeting @SPP2330 again! Great kick-off of our second funding period! Amazing science going on in the phage field and great to see students/postdocs from the first funding period starting their independent labs. @dfg_public, @fz_juelich, @HHU_de

Julia Frunzke @FrunzkeLab opening the annual @SPP2330 meeting! Looking forward to 3 exciting days of science! @dfg_public

We are ready to go for the Annual SPP2330 Meeting on “New Concepts in Prokaryotic Virus-host Interactions”! With a fantastic line up of speakers: Alexander Harms @AHarms485, Karen Maxwell @theMaxwellLab, Samuel Kilcher @SamuelKilcher, and Mathias Middelboe @mmiddelboe1

Rare opportunity to join my team, as the @PLOSBiology in-house editorial team is growing! It's a great team in a great journal, if I say so myself 😆 Please reach out if your have Qs & apply if interested!! UK or US; assoc or senior Please RT us241.dayforcehcm.com/Candid…

A supervisor, postdoc and the new PhD candidate x.com/i/status/1808987434752…

Congratulations to @UofT_dlsph postdoc fellow @michelle_olding on receiving the 2024 EPIC Career Transition Award to lead an independent project looking at the role of prescribed safer supply programs in improving access to HIV and HCV care! Read more: bit.ly/45x0Quk

Anti-phage defence through inhibition of virion assembly @theMaxwellLab @pramalpatel #phages #antiphage #prophages #phagedefence #bacteria #microbiology #virology nature.com/articles/s41467-0…

This is definitely one of the longest running projects in the lab b/c we were stuck in a trap of thinking about Sie proteins blocking competing phages. But wasn't a satisfying answer to fit the biology we observed - kudos to @vee_coli for persevering and figuring it out!

New prepint alert @themaxwelllab! 📢 📢 📢 Superinfection exclusion (Sie) proteins aren’t just for defence – they also ensure the spread of viral progeny! Prophages that lack Sie proteins devour their young via a process we call the Kronos effect. biorxiv.org/content/10.1101/…

I am thrilled to share our work on a novel prophage-encoded phage defence from @theMaxwellLab: Anti-phage defence through inhibition of virion assembly nature.com/articles/s41467-0…

This old dude band’s cover of Tiffany’s “I think we’re alone now” made.my.year.

Out today in @MolMicroEditors: Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in P aeruginosa doi.org/10.1111/mmi.15202 With our 🇨🇦 friends @DezielEric and @theMaxwellLab

Congratulations to Gary Bader, Benjamin Blencowe, Timothy Hughes and Mikko Taipale on their chair appointments! 👏 The appointments will support research in disease biomarkers, gene regulation and host-pathogen interactions. #UofT Learn more 👉 uoft.me/ChairAppointments