In the summer of 2010, David Fajgenbaum was everything a young man could hope to be. He had been a Division I college quarterback. He spoke multiple languages. He was in his third year at one of America's top medical schools, the University of Pennsylvania. He had his whole life mapped out in front of him. Then his body turned on him. Almost overnight, his organs began failing. His lymph nodes swelled. He was exhausted beyond anything he had ever felt. Within days, he was rushed to the emergency room. Weeks of testing followed. Finally, doctors gave it a name: Castleman disease — a rare and catastrophic condition where the immune system attacks the body's own organs. There was no cure. There was barely a treatment. A priest came to his hospital room and read his last rites. David said goodbye to his family. Then, somehow, an aggressive round of chemotherapy pulled him back from the edge. But it didn't hold. Within three years, he collapsed again. And again. And again. Five times in total, he came to the edge of death. Five times, chemotherapy bought him a little more time. After the fifth collapse, his doctors sat with him and said the words no patient wants to hear: his body had received the maximum amount of chemotherapy a human being can survive. If he relapsed again, there would be nothing left to give him. He would die. Most people, hearing that, would have spent whatever time remained saying goodbye. David Fajgenbaum picked up a medical journal From his hospital bed,between treatments, he began doing something no patient had ever done before — systematically studying his own disease with the full knowledge of a trained physician.He analyzed thousands of pages of his own medical records.He tested his own blood samples, looking for patterns invisible to everyone else because no one else had both the data and the desperate motivation to find them And he found something In his lymph node samples,a specific protein signaling pathway called mTOR was firing at abnormally high levels — essentially sending the immune system into a frenzy that destroyed his own organs. It was a clue no one had spotted because no one had looked in quite that way before. Then he searched for something that could stop it. He found it in an unlikely place: a medication called sirolimus, already approved and available, commonly used to prevent organ rejection after kidney transplants. No one had ever tried it for Castleman disease. But on paper, its mechanism was a near-perfect match for what David had found in his own blood. Under his doctor's supervision, he began taking it. Within days, his symptoms vanished. Not improved. Vanished. The man doctors had given up on walked out of the hospital. He finished medical school. He married his girlfriend Caitlin. He became a father. He became one of the youngest faculty members ever to receive tenure at Penn Medicine. And then he turned around to face everyone still waiting in the dark. He founded the Castleman Disease Collaborative Network, building the first global research effort for a disease that had none. He launched Every Cure — an organization that uses artificial intelligence to search all existing approved drugs for hidden matches with diseases that currently have no treatment. The idea is simple and revolutionary: there are over 1,500 approved drugs in the world and over 7,000 diseases with no treatment. The cures may already exist. They just haven't been matched yet. Over 15 years, Fajgenbaum and his partners have helped advance 28 repurposed drugs — 14 directly led by him. MedicalXpress A priest once came to read him his last rites. Today, David Fajgenbaum has authored over 100 scientific papers, appeared on TIME's list of the world's most influential people in health, and continues to take his small sirolimus tablet every single morning — the pill he found himself, in the darkest room of his life, when no one else was looking. He didn't wait to be saved. He became the person who figured out how.

i wasn't even going to play @MonmouthPark today I was gonna sit by pool But somehow found myself w my '23 Haskell hat on. Kept being alive 4 things, 1st p5 now p6 CHALKY but not as terrible as thought R5: 1,4,6 R6: 1,2,4,8 R7: 4,10 R8: 5,7 R9: 2,6,9 R10: 8 $28.80$203.52

Chalky but what can u do when @Pacolopez1018 wins 4 of THNX PACO R1: 3 R2: 2,3,6 R3: 1,4 R4: 1,6,7 R5: 2,4,6 $27.00 at least some shekels for this stupid new thing to get sucked into , a $5 - like $3 isn't enough - p3 2nt at @WoodbineSB @santaanita OF COURSE

Wondering Y @ScatoniSureShot not announcing on twtr that we will get full matrix (aka GRID) 4 @DelMarRacing this year not just contest race. As someone who a cpl times did well in contest - w/ DMR blanket and gym bag to prove it- I still missed grid & now we get both. YAY.

This is kind of shocking to me, who always just checks the organ donor box when renewing license without thinking..

Not watching or looking at any commentary re SAR today - shouldn’t even be betting, @DailyRacingForm laying on bed unopened - but notice Beckman D Whitworth trains the 1 . OTB rifraff friend who had Ocelli across board in Derby said he’s a trainer to watch out 4 @ToddTTV @loomsboldly

Oh I see you are talking to this $FLUT a hole too @TheJudgeCNBC Ask him if he even knows or cares the Belmont is this Sat after he DESTROYED TVG. people wouldn’t mind him getting killed by Kalshi

I see you have the $FLUT guy on @contessabrewer Why don’t you ask the a hole how he feels about the Belmont ( THIS Saturday , does he even KNOW?) now that he totally dismantled TVG which fans liked. you shouldn’t even TALK to him

Most interesting tweet I’ve seen today

Will watch later

plus he listens to ppl 3000 miles away yelling 'cmon jj' at their computers @FrankMirahmadi DB R8: 7 R9: 7 $5.00$0.00

Pix from expert harness player whose fav place in the world is 8 rows up at the finish line at CHESTER which we will never call @HarrahsPHL Haven’t had time even log in @TwinSpires & see if he’s been rt so far (circled numbers win pix) @NahuMikeeP @murrayslough

That was the chalkiest P6 @santaanitapark I can remember. Can’t believe I wasted any money or even worse time - which I don’t have this weekend - to get involved. And those P3s were almost worthless.

OMG was gonna say same to @BritneyEurton just now Belinda w/ that F%@#$kg phoney baloney smile. Britney ASK her Y she’s closing @LaurelPark leaving all the ACTUAL horseplayers in the DMV w a F#$g SCHLEP to @PimlicoRC or otbs . @Rosecroft only close one , others an hr away . F u Belinda

Totally agree w everything Brad Thomas said on @DownTheStretchR about 20 min ago. Everyone should listen to replay and scroll back to maybe 11:30. So true.

TVG main website was down just now but when I went to app it worked. @ToddTTV @loomsboldly @ScatoniSureShot @Quigleys_Corner let people know this. Maybe it’s just in my area.

Who needs @ChurchillDowns when @Gingras3 & @dexterdunn1 are at Chester on a gorgeous afternoon? Wish I was there .

What sane bettors wld do- 4get chasing those 2 day P 4s 5s 8s @ChurchillDowns @KentuckyDerby & use the $ @santaanitapark 4 2 day carryover . Obv most world’s $$ headed 2 KY but u got 2 days prior $ all 2 urself. A pop up grid wld be nice @ScatoniSureShot @NahuMikeeP @InTheMoneyMedia

I just spent 2 incredible weeks in Italy and it is so frustrating to come back to the U.S… How is it possible @RobertKennedyJr that the Italian food supply is so vastly superior. I literally ate bread at every meal, dessert multiple times per day, and generally ate way more than I do in the U.S. Not once did I have acid reflux. Not one headache, no digestive problems, and I didn’t gain any weight. If I ate the same way in the U.S. (I used to at times) I would have gone through a full bottle of Tums and Advil just to get through the day… WHY does the U.S. allow glyphosate in wheat, high fructose corn syrup in food and who knows what in our milk products? The difference in quality of life in Italy vs the U.S. is staggering from their common sense (anti corporate) food regulation. WHY aren’t more people upset about this? The U.S. is the richest country in the world and we eat like one of the poorest.

Started my Derby prep listening to @NahuMikeeP interview this guy Don Tiger @InTheMoneyMedia PLUS (worth the $) . So interesting & convincing I feel like not reading or listening 2 another thing, going 2 OTB & putting in exactly what he said. ( Except I am a huge believer @jockeyfranco haha.)