A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and @prof_horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.

The Mediterranean diet may be doing something really interesting at the mitochondrial level. People with high Mediterranean diet adherence had significantly higher levels of two mitochondrial-derived microproteins known as Humanin and SHMOOSE. These are emerging molecules involved in cell stress resistance, mitochondrial signaling, and healthy aging. What stood out is that specific Mediterranean diet foods, including olive oil, fish, and legumes were associated with higher microprotein levels. And Humanin was inversely associated with two markers of oxidative stress. We already know the Mediterranean diet supports cardiovascular and metabolic health. This study suggests that some of those benefits may be mediated through mitochondrial microproteins.

The Mediterranean diet may be doing something really interesting at the mitochondrial level. People with high Mediterranean diet adherence had significantly higher levels of two mitochondrial-derived microproteins known as Humanin and SHMOOSE. These are emerging molecules involved in cell stress resistance, mitochondrial signaling, and healthy aging. What stood out is that specific Mediterranean diet foods, including olive oil, fish, and legumes were associated with higher microprotein levels. And Humanin was inversely associated with two markers of oxidative stress. We already know the Mediterranean diet supports cardiovascular and metabolic health. This study suggests that some of those benefits may be mediated through mitochondrial microproteins.

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I just launched a longevity Rx platform. Prescriptions I personally use are there. v1 is live now. Includes access to: Tadalafil (Cialis) Metformin Oral Minoxidil Tretinoin Estradiol Acarbose We’re working with licensed doctors and pharmacies to make these medications accessible. Lots more in v2 coming next week.

Interested in hundreds of dollars of free peptides? Go to bed on time. It doses you with natural growth hormone. No injection. GH great for recovery, muscle synthesis, cellular repair. Dose is gated to first night’s sleep window. You miss the dose if you miss the window.