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vosslab @voss_lab

Biochemistry/cell biology research group @kieluni | proteolytic processing of Golgi enzymes and Golgi organisation | PI tweeting | now mainly at bsky

Joined February 2022
  • Tweets 35
  • Following 142
  • Followers 67
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My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! Deadline: May 1st. #glycotime #SPPL3
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Wolf Lab for Tumor Biochemistry@_WolfLab
9 Apr 2025
We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!
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Wolf Lab for Tumor Biochemistry@_WolfLab
6 Jan 2025
Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: doi.org/10.1093/nar/gkae1219. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcrip...

Abstract. Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses to environmental changes. It is therefore no surprise t

academic.oup.com
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Markus Damme@DammeMarkus
19 Dec 2024
Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! grc.org/lysosomal-diseases-c…
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J Cell Science@J_Cell_Sci
18 Dec 2024
Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

ALT Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

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The EMBO Journal@embojournal
16 Dec 2024
Our final 2024 issue! Highlight: New players in lysosomal sorting via mannose-6-phosphate mRNA deadenylation & decay relations Plant ALBA proteins facilitate m6A reading and lots more! Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al embopress.org/toc/14602075/4…
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vosslab@voss_lab
11 Dec 2024
Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion. onlinelibrary.wiley.com/doi/…

Tumor‐Expressed SPPL3 Supports Innate Antitumor Immune Responses

Tumor and immune cells interact through receptor–ligand interactions. B3GNT5 produces nsGSL on tumor cells which is regulated by SPPL3. When SPPL3 is absent, elevated nsGSL levels hinder receptor–l...

onlinelibrary.wiley.com
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WinterLab@LysoProteomics
3 Dec 2024
Great collaboration with the @voss_lab out now in EMBO Journal! Congratulations Matthias for this nice work!
The EMBO Journal@embojournal
2 Dec 2024
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Sabrina Jabs, Matthias Voss et al embopress.org/doi/full/10.10…
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Wolf Lab for Tumor Biochemistry@_WolfLab
9 Dec 2024
Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. pubmed.ncbi.nlm.nih.gov/3964…

Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced...

The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized...

pubmed.ncbi.nlm.nih.gov
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vosslab retweeted
The EMBO Journal@embojournal
2 Dec 2024
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Sabrina Jabs, Matthias Voss et al embopress.org/doi/full/10.10…
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vosslab retweeted
Cell Biology J-Club@cell_club
25 Nov 2024
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Journal embopress.org/doi/full/10.10…

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate...

The EMBO Journal - Glycosylation, which plays an important role in modifying lipids and sorting of proteins, is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi...

link.springer.com
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vosslab@voss_lab
26 Nov 2024
Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh
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vosslab@voss_lab
23 Jul 2024
New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 doi.org/10.1016/j.bbagen.202…
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Markus Damme@DammeMarkus
26 Jun 2024
I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or tinyurl.com/yrv4bh22 Get in touch with me! Repost & spread the word!
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vosslab retweeted
Wolf Lab for Tumor Biochemistry@_WolfLab
11 Jun 2024
We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!
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vosslab retweeted
Cell Biology J-Club@cell_club
19 Apr 2024
Happy Golgi Day
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vosslab retweeted
Tak Sekine@SekineTak
19 Dec 2023
Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣️ ki.varbi.com/what:job/jobID:…

Forskningsassistent inom T-cellbiologi / Mänsklig immunologi

Vill du bidra till en bättre hälsa för alla? Sekine-gruppen söker en motiverad forskningsassistent för laborativ- och teknisk support. Vår forskning fokuserar på att karakterisera mekanismerna

ki.varbi.com
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vosslab@voss_lab
13 Dec 2023
Exciting and comprehensive paper - and notably another study that underscores the physiological relevance of SPPL3
Olli Dufva@ollidufva
12 Dec 2023
Our resource on NK cell - cancer interactions is now out in @ImmunityCP cell.com/immunity/fulltext/S… We identify tumor-induced NK cell states at single-cell resolution and tumor-intrinsic resistance mechanisms using CRISPR functional genomics Explore: immunogenomics.shinyapps.io/… 1/
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vosslab@voss_lab
31 Jul 2023
Finally managed to find time for another round of #cytosis with the lab.
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vosslab@voss_lab
17 Jun 2023
Congratulations to Neele and Stefan on their recent paper in BBA Mol Cell Res, glad we could contribute authors.elsevier.com/c/1hGJO…
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