wrote up an experiment I put together to try giving MHC-I peptides to agents: alexanderhonkala.com/posts/a…

Quick thoughts on pharmacodynamic response envelopes and how detangling their components can get us better insight into drug development: alexanderhonkala.com/post.ht…

finally got a chance to read this and the logistics base of 2000 target-to-Phase-2 projects is immense on preclinical & cGMP alone, daunting to think through sam-rodriques.com/post/the-h… but pushing for fast Phase 0 trials for PD target engagement may help

heard the phrase "use AI to cure cancer!" a lot at NeurIPS this year and it bothered me, so I wrote about it: alexanderhonkala.com/post.ht…

Hi, I’m David Brückner @d_brueckner. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information. x.com/EpiMechFC/status/18254…

inb4 phase mediated stress granule memory tracking via time recording exosomes for Schekman’s 2nd Nobel cell.com/cell-reports-physic…

this is why I really want a home mass spec appliance: ppl deserve to be able to get good data about chemical composition and exposures in products & built environments *that does not depend* on the largesse of mfgrs in order to make informed choices about their exposures

this is awesome new work, immediately made me think of plasticity as topology a la Chaffer & Krishnaswamy: ncbi.nlm.nih.gov/pmc/article… how is AP-1 pushing would-be forgetters back down the hill to form more stable treatment memories?

Today we launched a new Request for Content for articles covering technology development roadmaps, gap analyses, & missing dataset justifications: researchhub.com/post/2185/re… We're trying out paying authors to write great content instead of making them pay us just to publish! #DeSci

anyone seen a good ref for the technical approaches being explored for overcoming the GvHD issues of allogeneic cell therapies, ideally w a breakdown of what's happened clinically so far?

#MysterySolved! Krönke &co show @Nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! Doi.org/10.1038/s41586-024-0…

absolutely nutty that we accept a system where scientists aren't *paid* to publish groundbreaking new work but instead *compete* to *pay* for the privilege of publishing somewhere prestigious

Want to change the system? Post preprints and only post preprints - don't submit to journals, don't subscribe to journals, don't read journals - only hire and fund people based on their preprints.

A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions A new 5′ untranslated region (UTR) Language Model! - Pretrain the model with mask prediction, 5' UTR secondary strcuture prediction, and minimum free energy prediction - Finetune [CLS] token for downstream tasks - Experimental validation shows designed UTRs increases protein production level

Our lab's newest preprint is out now! We report that airway injury can trigger changes in distant areas of the lungs that were not previously appreciated. We dove into the amazing field of macrophage biology to explain these responses. Check out our story: biorxiv.org/content/10.1101/…

cool NBER paper (pdf) on the interactions of public vs private R&D spending: nber.org/system/files/workin…