Morphogens in the evolution of size, shape and patterning
In this Review, Lewis Mosby, Amy Bowen and @z_hvas@TheCrick@UCL explore how morphogen-mediated patterning evolve and how theory and experiment can be interwoven to bring new perspectives:
journals.biologists.com/dev/…
ALT Figure 3: Examples where modulation of morphogen signalling maps to changes in patterning and form between species
Interested in how cells make decisions? Want to build new tools and model embryonic development using ESCs?
Come join us @MRC_LMS! We have a #postdoc position open in the area of gene regulation, stem cells and mouse development.
See how to apply here: lms.mrc.ac.uk/vacancies/mrc-…
Back from an incredible joint retreat with @BertaVerd’s lab! Filled with discussions on morphogenesis, evolution, GRNs, birds, and fishes 🐦🐟 (though sadly, the fishes couldn’t join us this time). Grateful for the inspiring exchange of ideas!
What a fantastic couple of days at the London Math Biology Conference hearing all about the very diverse applications of maths in biology. Watch this space for the UK-wide event next fall. Huge thanks to @pearce_maths, @2piruben@TheCrick events team and all the presenters 💥
After months of preparation the London Mathematical Biology Conference is kicking off! Ready to enjoy two days of fantastic talks, posters, and conversations.
Interested in applying for a fellowship to do a PhD @unil with my lab (bacterial synthetic biology) as a host? Send me a CV and a motivation letter till September 6th!
unil.ch/ecoledoctoralefbm/en…
⌛️Last call⌛️ to register to the London Mathematical Biology Conference! Join us September 8-9 at the Francis Crick Institute for the event of the year. Check out the preliminary program and registration details on our webpage crick.ac.uk/whats-on/london-…
🍄 More mushroom magic ! This time we show that nearby bifurcations lead to synergistically slower dynamics that are robust to noise and can be used to encode genetic timers ⏳🧬. Thanks to @JosepSardanyes @MathSMaret@FuchoMariona and the rest of the team
biorxiv.org/content/10.1101/…
ALT Picture of the last lab trip, a visit to Bletchley Park. The statue in the picture is of Alan Turing, who, in addition to helping crack the German coded messages during WWII, also worked in biomathematics and actually coined the term ‘morphogen’. Charlotte and Ruben are on the left side of the picture.
ALT Studying orbits of gene expression to understand developmental tempo. A common gene regulatory network across species (left) is expected to have different biochemical parameters that results in different gene expression trajectories (middle). Nevertheless, the function can be captured by studying the orbit of gene expression (right).
Excited to share our new paper building a mathematical framework to study developmental tempo differences across species using orbital equivalence 🕐🐁↔️🕑🐒
Grateful to count with @clmanser in the team!
journals.biologists.com/dev/…
Registration is now open! Join us for another edition of biomaths extravaganza. Deadline for contributions is July 20th 🗓️, we can't wait to see your proposals👀
📢 Save the date for the next London Mathematical Biology Conference, happening 9-10/9/24 @TheCrick. Registration opens soon with many opportunities for contributed talks and abstracts. Spread the word!
📢 Save the date for the next London Mathematical Biology Conference, happening 9-10/9/24 @TheCrick. Registration opens soon with many opportunities for contributed talks and abstracts. Spread the word!
Proud to present @callumbucklow's first paper from his DPhil, and first paper from my lab! A ready to use, whole-body uCT-scan dataset of Lake Malawi cichlid fishes for your enjoyment and research. Feel free to browse. The 3d models are awesome.
Well done Callum!
My first manuscript (!) is now ready and accessible here: doi.org/10.1101/2023.11.01.5…. We describe a whole-body uCT-scan dataset of 56 species (116 individuals) of Lake Malawi cichlid fishes. It's been a huge effort and I'm really happy to finally be able to share it.