Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @RMedzhitov @YaleIBIO nature.com/articles/s41577-0…

A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue

New review out! 😊 20 years after its discovery, with @iannaconelab we decided to bring together what we currently know about this cytokine and how it shapes CD8 T cell responses. A small contribution to make sense of a field that is moving fast 🌈

Can I be MORE proud?? 🥹 Amazing and inspiring as always @ValentinaVenzin 💕

✨ That’s a wrap on The Power of Multiplexed Imaging! A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis! Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈 #MultiplexImaging #SpatialBiology

Happy to share our latest review "Targeting HBV with RNA interference: Paths to cure" | Science Translational Medicine science.org/doi/10.1126/scit… written together with @CristianBecc, Lena Allweiss, Julie Lucifora, John Tavis, @DrAGehring and Maura Dandri

Thrilled to share that it’s finally out! I had the chance to contribute, and I’m incredibly proud and grateful to the two first authors — not only brilliant scientists, but truly inspiring mentors! So happy to see this work published! 💙 @iannaconelab nature.com/articles/s41590-0…

1/ 🚨 Hot off the press in @NatImmunol: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. nature.com/articles/s41590-0… 🧵(1/11) 2/ Chronic HBV infection was the perfect stress test: intrahepatic CD8⁺ T cells are primed yet quickly stall. How to reignite them has been a major interest of our lab. (2/11) 3/ Pre‑activated helper CD4⁺ T cells solve the puzzle. They skip lymph nodes and head straight to the liver, where they form intimate triads with Kupffer cells (KCs), the resident macrophages patrolling sinusoids. (3/11) 4/ Through CD40L‑CD40 contact, those helpers re‑program KCs—turning tolerant scavengers into potent APC‑like cytokine factories. It’s on‑site immune engineering, not remote coaching. (4/11) 5/ Licensed KCs release a two‑part cocktail: • IL‑12 expands the helper pool • IL‑27 wakes up dysfunctional CD8⁺ T cells, restoring effector molecules and metabolic vigor. (5/11) 6/ Dendritic cells? Dispensable. Secondary lymphoid organs? Surgically removed or pharmacologically blocked—help still flows. Immunity can be fabricated in situright inside the parenchyma. (6/11) 7/ Remove KCs and the circuit collapses; block CD40L or IL‑27 and CD8⁺ T cells relapse into lethargy. The essential loop is: CD4 T cell ➜ KC ➜ IL‑27 ➜CD8 T cell. (7/11) 8/ IL‑27 isn’t just necessary—it’s sufficient. Recombinant IL‑27 revived antiviral CD8⁺ activity in mice and super‑charged HBV‑specific T cells from patients. (8/11) 9/ Why care beyond HBV? Tapping a CD4–IL‑27 axis could be a universal key to re‑arming liver‑resident CD8⁺ T cells against infections and cancer (9/11) 10/ The work reframes “CD4 help”: not a lymph‑node pep talk but an on‑site renovation that overrides local tolerance. Therapeutics that mimic KC licensing could deliver potency where it’s needed and spare the rest of the body. (10/11) 11/ Kudos to Valentina Venzin, Cristian Beccaria, all members of the @IannaconeLab & collaborators for charting this intrahepatic circuit. Expect Kupffer‑cell licensing and IL‑27 to enter conversations on cancer immunotherapy, vaccines and beyond. Thoughts welcome! 🙌 @ImmunoPodcast @profvrr @ERC_Research @EMBO @EMBO_YIP @ArmeniseHarvard @AIRC_it @MyUniSR @SanRaffaeleMI (11/11)

We had a great time at #SIICA2025 in beautiful Perugia! 🌿 It was a pleasure to share our research, connect with the community, and be inspired by so much great science. Special shoutout to our @GiuseppeRocca16 for winning the Best Poster Award – well deserved! 🏆🎉 #Immunology

🚀 Registrations are OPEN! Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology. 🔬 Inspiring talks, hands-on training, cutting-edge tech! Secure your spot 👉 academy.unimib.it/power-adva… #MultiplexedImaging #SpatialBiology #ImagingCourse

✨ Reminiscing about last year’s multiplexed imaging course—such a fantastic experience! 🤩 We were thrilled to have @colinchu72, along with all the students & guests! Truly inspiring days of learning. Big things coming—stay tuned! 👀🚀🔬 #SpatialBiology #MultiplexImaging

Excited to share our new editorial in Nanomedicine on engineering immunity with nanoparticles! 🧬✨ We explore insights into recent advances in transplant rejection therapy. A must-read for #Nanomedicine & #TransplantImmunology! doi.org/10.1080/17435889.202… @dendriticell @Ste_cozzi

Super excited to finally post about our neutrophil project, led by our very own @GiuliaStucchi2. 🎉 We discovered an unforeseen two-tier mechanism of neutrophil recruitment during infections, in which mechanosensing is key to initiating innate immunity. biorxiv.org/content/10.1101/…

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Thrilled to have participated in #ECI2024 ! ☘️🎉 Our lab had the incredibile opportunity to connect with leading experts, share our research, and explore latest breakthroughs in immunology. Feeling inspired and energised for what’s next! 🔬💡

Check out our latest publication now online @JHepatology, where we summarize key and emerging concepts on the complex immune response to #HepatitisB virus. Kudos to @VenzinValentina, @CristianBecc, @frarro1, and @ValeFuma91 for spearheading this! sciencedirect.com/science/ar…

#LocationLocationLocation! @GiuseppeRocca16 @ACelant2 @dendriticell @GiuliaStucchi2 @Ste_cozzi @Metello_Inn @GranucciLab discuss @FEBS_Letters new #spatial imaging techs to get new insights into the biology & functions of dendritic cells #DCs! #MustRead! doi.org/10.1002/1873-3468.14…