Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse...

Nature Communications - Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing...

Submicrometre sampling of living cells by macrophages

Nature - Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown...

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens

The EMBO Journal - T cells use their T-cell receptors (TCRs) to discriminate between higher-affinity foreign and lower-affinity self-peptide-MHC (pMHC) antigen complexes. The OT-I mouse TCR is...

Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer

Specialized fibroblastic reticular cells (FRCs) underpin interconnected T cell environments with dedicated microenvironmental niches for FRC-T cell interaction, which promotes antitumor immunity in...

Cells Get Overworked Too: The Effect of T Cell Exhaustion in Cancer

Reading time: 6 minutes Gracie Jennah Mead Introduction  Exhausted T cells (Tex) were first discovered during chronic viral infections whereby the CD8 T cells (which are a type of immune cell …

DPhil in Cancer Science

A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel...

Nature Immunology - In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pretreatment...

Cellular roadmap reveals new paths to treating inflammatory bowel disease

In a world first, researchers at the Kennedy Institute, Oxford have mapped the cellular dynamics following treatment with the most commonly used advanced therapy in autoimmune diseases. They have...