Joined March 2020
- Tweets 470
- Following 314
- Followers 820
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Pinned Tweet
How lytic cell death drives autoantigen release and fuels inflammation? With @lynndustinlab we ask this using a common autoantigen, TRIM21. The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death | Science Immunology science.org/eprint/VEVN4EQK8…
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JelenaBezbradicaLab retweeted
Apr 18
Interferons in health and disease.
Check out this review by @Lo_Zanzi & Daniel Boehmer in @CellCellPress #AAI2026 hubs.li/Q04c5DJg0
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JelenaBezbradicaLab retweeted
Calling all Inflammazoomers: after brilliant talks from Siddharth Balachandran, Marcus Taylor, Katia Cosentino and Tanita Wein (catch up on the Abcam Hub) this Thurs we have 2 more..... Rachel Lai and Jueqi Chen GMT 15:00 1
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New from Clare Bryant and team. Characterisation of endogenous TRIFosome and how it dictates the outcome of TLR signalling. Beautiful work!
TRIFosomes found😀. Very proud of our team’s work to identify endogenous TRIFosome. Surprisingly whilst TRIFosomes activate NFKB, IFN signaling is from monomeric or dimeric TRIF. doi.org/10.1126/sciadv.aeb95…
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JelenaBezbradicaLab retweeted
Hot off the biorxiv press! 🔥 @SamuelLaraR finds GBP5 enhances macrophage glycolysis via glucose uptake, GTPase activity dependent and as being cis-Golgi localised. Bonus finding, GBP5 is important for full M1 macrophage functionality.
biorxiv.org/content/10.64898…
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Next on Inflammazoom gasdermins with Katia Cosentino and Tanita Wein Monday at 1 GMT
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20 Oct 2025
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
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JelenaBezbradicaLab retweeted
19 Oct 2025
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v_hornung &co show @CellCellPress that RNase T2 & PLDs generate #TLR7 & 8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing sciencedirect.com/science/ar…
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17 Oct 2025
Looking forward to hosting James Murphy @pseudokinase and Jonathan Maelfait @InflamResCen as #InflammaZoom speakers on Monday October 20th. Register below via Abcam link for this free Webinar.
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
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16 Oct 2025
Do not miss this! #inflammazoom is back in October 🎉 with James Murphy from WEHI and Jonathan Maelfait from VIB Ghent we are back with some really 🔥 stories!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
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21 Sep 2025
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JelenaBezbradicaLab retweeted
3 Aug 2025
New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
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JelenaBezbradicaLab retweeted
2 Sep 2025
Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
2 Sep 2025
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. hubs.la/Q03GtbGx0
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JelenaBezbradicaLab retweeted
30 Jul 2025
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
@harvardmed @BostonChildrens
royalsocietypublishing.org/d…
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JelenaBezbradicaLab retweeted
17 Jul 2025
Thanks for highlighting the preprint of our work, now online @CellCellPress authors.elsevier.com/sd/arti…
17 Jul 2025
BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU
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JelenaBezbradicaLab retweeted
17 Jul 2025
📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was fun being part of this with Tate group and many others. pubs.acs.org/doi/10.1021/acs…
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JelenaBezbradicaLab retweeted
17 Jul 2025
Discovery of a pH sensor that regulates inflammation.
Zhou and Medzhitov provide a mechanistic tour-de-force in defining how BRD4 links changes in pH to inflammatory gene expression. Kudos to the authors on this exciting finding.
sciencedirect.com/science/ar…
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JelenaBezbradicaLab retweeted
17 Jul 2025
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g…
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JelenaBezbradicaLab retweeted
8 Jul 2025
Abstract submission deadline is getting close! Don't get out of this superb conference!
Inflammation 🔥
26 Jun 2025
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with @BSI_Inflam on 11–12 Sept in Manchester!
Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!
☑️ Submit your abstract & register: bit.ly/43q9x9r
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JelenaBezbradicaLab retweeted
28 May 2025
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
Abstract deadline: 15 July
Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
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